TY - JOUR
T1 - Biochemical Analysis of Aqueous Humor in an Elderly Patient with Multiple Myeloma Presenting First as Bilateral Chronic Uveitis
AU - Agarwal, Mamta
AU - Vijayaraghavan, Mridula
AU - Muthuvel, Bharathselvi
AU - Narayanasamy, Angayarkanni
N1 - Publisher Copyright:
© 2023 Taylor & Francis Group, LLC.
PY - 2024
Y1 - 2024
N2 - Purpose: To study the biochemical analysis of aqueous humor in a patient with multiple myeloma presenting first as chronic uveitis. Methods: Observational case report. Results: A 63-year-old healthy woman presented with blurred vision in both eyes for 9 months. Slit-lamp examination showed bilateral conjunctival congestion, corneal oedema, and anterior uveitis. Fundus exam revealed normal optic disc with fine retinal folds in the macula. Serum protein electrophoretogram showed a monoclonal M protein band in the gamma globulin region. The bone marrow biopsy revealed hypercellular marrow with trilineage haematopoiesis and the bone marrow aspirate showed clonal plasma cells >10%, confirming the diagnosis of multiple myeloma. Aqueous fluid showed a differential band in electrophoretic profile of aqueous humor protein that on mass spectrometry analysis was strongly suggestive of immunoglobulin band. Conclusion: The biochemical analysis of aqueous humor is another diagnostic test to monitor M protein in patients with multiple myeloma.
AB - Purpose: To study the biochemical analysis of aqueous humor in a patient with multiple myeloma presenting first as chronic uveitis. Methods: Observational case report. Results: A 63-year-old healthy woman presented with blurred vision in both eyes for 9 months. Slit-lamp examination showed bilateral conjunctival congestion, corneal oedema, and anterior uveitis. Fundus exam revealed normal optic disc with fine retinal folds in the macula. Serum protein electrophoretogram showed a monoclonal M protein band in the gamma globulin region. The bone marrow biopsy revealed hypercellular marrow with trilineage haematopoiesis and the bone marrow aspirate showed clonal plasma cells >10%, confirming the diagnosis of multiple myeloma. Aqueous fluid showed a differential band in electrophoretic profile of aqueous humor protein that on mass spectrometry analysis was strongly suggestive of immunoglobulin band. Conclusion: The biochemical analysis of aqueous humor is another diagnostic test to monitor M protein in patients with multiple myeloma.
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U2 - 10.1080/09273948.2023.2229416
DO - 10.1080/09273948.2023.2229416
M3 - Letter
C2 - 37429027
AN - SCOPUS:85164697796
SN - 0927-3948
VL - 32
SP - 1479
EP - 1483
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 7
ER -