Biochemical Analysis of Aqueous Humor in an Elderly Patient with Multiple Myeloma Presenting First as Bilateral Chronic Uveitis

Mamta Agarwal, Mridula Vijayaraghavan, Bharathselvi Muthuvel, Angayarkanni Narayanasamy

Research output: Contribution to journalLetterpeer-review

Abstract

Purpose: To study the biochemical analysis of aqueous humor in a patient with multiple myeloma presenting first as chronic uveitis. Methods: Observational case report. Results: A 63-year-old healthy woman presented with blurred vision in both eyes for 9 months. Slit-lamp examination showed bilateral conjunctival congestion, corneal oedema, and anterior uveitis. Fundus exam revealed normal optic disc with fine retinal folds in the macula. Serum protein electrophoretogram showed a monoclonal M protein band in the gamma globulin region. The bone marrow biopsy revealed hypercellular marrow with trilineage haematopoiesis and the bone marrow aspirate showed clonal plasma cells >10%, confirming the diagnosis of multiple myeloma. Aqueous fluid showed a differential band in electrophoretic profile of aqueous humor protein that on mass spectrometry analysis was strongly suggestive of immunoglobulin band. Conclusion: The biochemical analysis of aqueous humor is another diagnostic test to monitor M protein in patients with multiple myeloma.

Original languageEnglish (US)
JournalOcular Immunology and Inflammation
DOIs
StateAccepted/In press - 2023
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy

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