Bioactive factors and biosynthetic materials in bone grafting

J. O. Hollinger; A. E. Seyfer

Bioactive factors and biosynthetic materials in bone grafting

Research output: Contribution to journal › Review article › peer-review

Abstract

The ability to initiate bone repair with bioactive factors and delivery systems is contingent upon understanding and mimicking biochemical and cellular events that occur in response to autograft and allograft repair. This review develops the concept that osseous repair must be linked to a time-dependent sequence of structured events, the chronobiologic continuum of wound repair. Selected factors that have shown promise for promoting bone formation are discussed. The deployment of select factors by a biodegradable delivery system that fulfills physiologic requirements for osseous repair is explored.

Original language	English (US)
Pages (from-to)	415-418
Number of pages	4
Journal	Clinics in Plastic Surgery
Volume	21
Issue number	3
State	Published - Jan 1 1994
Externally published	Yes

ASJC Scopus subject areas

Surgery

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title = "Bioactive factors and biosynthetic materials in bone grafting",

abstract = "The ability to initiate bone repair with bioactive factors and delivery systems is contingent upon understanding and mimicking biochemical and cellular events that occur in response to autograft and allograft repair. This review develops the concept that osseous repair must be linked to a time-dependent sequence of structured events, the chronobiologic continuum of wound repair. Selected factors that have shown promise for promoting bone formation are discussed. The deployment of select factors by a biodegradable delivery system that fulfills physiologic requirements for osseous repair is explored.",

author = "Hollinger, {J. O.} and Seyfer, {A. E.}",

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AB - The ability to initiate bone repair with bioactive factors and delivery systems is contingent upon understanding and mimicking biochemical and cellular events that occur in response to autograft and allograft repair. This review develops the concept that osseous repair must be linked to a time-dependent sequence of structured events, the chronobiologic continuum of wound repair. Selected factors that have shown promise for promoting bone formation are discussed. The deployment of select factors by a biodegradable delivery system that fulfills physiologic requirements for osseous repair is explored.

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