Binding pattern of [³⁵S]t-butylbicyclophosphorothionate is not altered following electroconvulsive shock treatment in rats

Single or repeated electroconvulsive shock (ECS) treatment-induced changes in [³⁵S]t-butylbicyclophosphorothionate ([³⁵S]TBPS) binding patterns in specific regions i.e., cerebral cortex, cerebellum, hippocampus, and striatum of rat brain were investigated. Specific[³⁵S]TBPS binding in these brain regions was not altered following a single or repeated administration of ECS, nor was the inhibition of [³⁵S]TBPS binding by GABA affected. These observations tend to suggest that the picrotoxin-site on the GABA receptor complex may not be directly involved in electroconvulsive shock.