Binding pattern of [35S]t-butylbicyclophosphorothionate is not altered following electroconvulsive shock treatment in rats

Shrinivas K. Kulkarni, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Single or repeated electroconvulsive shock (ECS) treatment-induced changes in [35S]t-butylbicyclophosphorothionate ([35S]TBPS) binding patterns in specific regions i.e., cerebral cortex, cerebellum, hippocampus, and striatum of rat brain were investigated. Specific[35S]TBPS binding in these brain regions was not altered following a single or repeated administration of ECS, nor was the inhibition of [35S]TBPS binding by GABA affected. These observations tend to suggest that the picrotoxin-site on the GABA receptor complex may not be directly involved in electroconvulsive shock.

Original languageEnglish (US)
Pages (from-to)575-577
Number of pages3
JournalBrain Research Bulletin
Volume22
Issue number3
DOIs
StatePublished - Mar 1989

Keywords

  • Electroconvulsive shock
  • GABA receptor complex
  • Picrotoxin
  • Seizures
  • TBPS

ASJC Scopus subject areas

  • Neuroscience(all)

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