Binding of sperm to somatic cells via HLA-DR: Modulation by sulfated carbohydrates

V. L. Scofield, R. Clisham, L. Bandyopadhyay, P. Gladstone, L. Zamboni, R. Raghupathy

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

We have shown previously that human sperm bind and enter leukocytes expressing surface HLA class II molecules. In the present study, mutant B lymphoblastoid cells and HLA-DR-transfected murine 3T3 fibroblasts are used to confirm that HLA class II molecules are somatic cell receptors for sperm. Further, for isolated HLA-DR expressed on murine cells, we show that sperm receptor activity requires the presence of sulfated carbohydrates. As carriers of multiple HLA-DR binding ligands, sperm may 1) mimic the target cell-activating effects of anti-DR antibody and 2) bind HIV through CD4-like or alternate receptors. By these or other mechanisms, sperm/somatic cell interactions in the female reproductive tract may affect fertility and potentiate the sexual transmission of AIDS.

Original languageEnglish (US)
Pages (from-to)1718-1724
Number of pages7
JournalJournal of Immunology
Volume148
Issue number6
StatePublished - 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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