Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

A. Kootstra, T. J. Slaga

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.

Original languageEnglish (US)
Pages (from-to)954-959
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume93
Issue number3
DOIs
StatePublished - Apr 14 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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