Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

A. Kootstra; T. J. Slaga

doi:10.1016/0006-291X(80)91168-7

Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

A. Kootstra, T. J. Slaga

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.

Original language	English (US)
Pages (from-to)	954-959
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(80)91168-7
State	Published - Apr 14 1980
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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title = "Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin",

abstract = "Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.",

author = "A. Kootstra and Slaga, {T. J.}",

note = "Funding Information: Research supported by NIH Research, U.S. Department Carbide Corporation. t Send correspondence Present address: Research, CH-1066 Funding Information: Grant CA 20076 and the Office of Health of Energy, under contract W-7405-eng-26",

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doi = "10.1016/0006-291X(80)91168-7",

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AU - Kootstra, A.

AU - Slaga, T. J.

N1 - Funding Information: Research supported by NIH Research, U.S. Department Carbide Corporation. t Send correspondence Present address: Research, CH-1066 Funding Information: Grant CA 20076 and the Office of Health of Energy, under contract W-7405-eng-26

PY - 1980/4/14

Y1 - 1980/4/14

N2 - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.

AB - Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.

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Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

Abstract

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