Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

A. Kootstra; T. J. Slaga

doi:10.1016/0006-291X(80)91168-7

Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

A. Kootstra, T. J. Slaga

Pharmacology

Research output: Contribution to journal › Article

14 Scopus citations

Abstract

Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.

Original language	English (US)
Pages (from-to)	954-959
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	93
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(80)91168-7
State	Published - Apr 14 1980

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ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Cite this

Kootstra, A., & Slaga, T. J. (1980). Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin. Biochemical and Biophysical Research Communications, 93(3), 954-959. https://doi.org/10.1016/0006-291X(80)91168-7

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10.1016/0006-291X(80)91168-7