Abstract
Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.
Original language | English (US) |
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Pages (from-to) | 954-959 |
Number of pages | 6 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 93 |
Issue number | 3 |
DOIs | |
State | Published - Apr 14 1980 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology