Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin

A. Kootstra, Thomas J Slaga

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Both the carcinogenic B[a]P diol-epoxide (anti) and its relatively noncarcinogenic isomer, B[a]P diol-epoxide (syn), when reacted with chromatin in vitro, bind more extensively to the internucleosomal region of chromatin than to nucleosomes. These results suggest that the increased binding of B[a]P diol-epoxide (anti) to the internucleosomal region may have little relevance to the process of carcinogenesis.

Original languageEnglish (US)
Pages (from-to)954-959
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume93
Issue number3
DOIs
StatePublished - Apr 14 1980
Externally publishedYes

Fingerprint

Benzo(a)pyrene
Epoxy Compounds
Isomers
Chromatin
Nucleosomes
Carcinogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Binding of isomers of benzo[a]pyrene diol-epoxide to chromatin. / Kootstra, A.; Slaga, Thomas J.

In: Biochemical and Biophysical Research Communications, Vol. 93, No. 3, 14.04.1980, p. 954-959.

Research output: Contribution to journalArticle

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