Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Zhuobin Liang; Fengshan Liang; Yaqun Teng; Xiaoyong Chen; Jingchun Liu; Simonne Longerich; Timsi Rao; Allison M. Green; Natalie B. Collins; Yong Xiong; Li Lan; Patrick Sung; Gary M. Kupfer

doi:10.1016/j.celrep.2018.12.084

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Zhuobin Liang
, Fengshan Liang
, Yaqun Teng
, Xiaoyong Chen
, Jingchun Liu
, Simonne Longerich
, Timsi Rao
, Allison M. Green
, Natalie B. Collins
, Yong Xiong
, Li Lan
, Patrick Sung
, Gary M. Kupfer

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

Original language	English (US)
Pages (from-to)	564-572.e5
Journal	Cell Reports
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2018.12.084
State	Published - Jan 15 2019

Keywords

DNA damage
FANCD2
FANCI-FANCD2
Fanconi anemia
R-loop
RNA
monoubiquitination
transcription perturbation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.12.084

Cite this

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title = "Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination",

abstract = "Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.",

keywords = "DNA damage, FANCD2, FANCI-FANCD2, Fanconi anemia, R-loop, RNA, monoubiquitination, transcription perturbation",

author = "Zhuobin Liang and Fengshan Liang and Yaqun Teng and Xiaoyong Chen and Jingchun Liu and Simonne Longerich and Timsi Rao and Green, \{Allison M.\} and Collins, \{Natalie B.\} and Yong Xiong and Li Lan and Patrick Sung and Kupfer, \{Gary M.\}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2019",

month = jan,

day = "15",

doi = "10.1016/j.celrep.2018.12.084",

language = "English (US)",

volume = "26",

pages = "564--572.e5",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

AU - Liang, Zhuobin

AU - Liang, Fengshan

AU - Teng, Yaqun

AU - Chen, Xiaoyong

AU - Liu, Jingchun

AU - Longerich, Simonne

AU - Rao, Timsi

AU - Green, Allison M.

AU - Collins, Natalie B.

AU - Xiong, Yong

AU - Lan, Li

AU - Sung, Patrick

AU - Kupfer, Gary M.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

AB - Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

KW - DNA damage

KW - FANCD2

KW - FANCI-FANCD2

KW - Fanconi anemia

KW - R-loop

KW - RNA

KW - monoubiquitination

KW - transcription perturbation

UR - https://www.scopus.com/pages/publications/85059819767

UR - https://www.scopus.com/pages/publications/85059819767#tab=citedBy

U2 - 10.1016/j.celrep.2018.12.084

DO - 10.1016/j.celrep.2018.12.084

M3 - Article

C2 - 30650351

AN - SCOPUS:85059819767

SN - 2211-1247

VL - 26

SP - 564-572.e5

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Abstract

Keywords

ASJC Scopus subject areas

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