Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Zhuobin Liang; Fengshan Liang; Yaqun Teng; Xiaoyong Chen; Jingchun Liu; Simonne Longerich; Timsi Rao; Allison M. Green; Natalie B. Collins; Yong Xiong; Li Lan; Patrick Sung; Gary M. Kupfer

doi:10.1016/j.celrep.2018.12.084

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Zhuobin Liang, Fengshan Liang, Yaqun Teng, Xiaoyong Chen, Jingchun Liu, Simonne Longerich, Timsi Rao, Allison M. Green, Natalie B. Collins, Yong Xiong, Li Lan, Patrick Sung, Gary M. Kupfer

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

Original language	English (US)
Pages (from-to)	564-572.e5
Journal	Cell Reports
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2018.12.084
State	Published - Jan 15 2019

Keywords

DNA damage
FANCD2
FANCI-FANCD2
Fanconi anemia
R-loop
RNA
monoubiquitination
transcription perturbation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2018.12.084

Cite this

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title = "Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination",

abstract = "Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.",

keywords = "DNA damage, FANCD2, FANCI-FANCD2, Fanconi anemia, R-loop, RNA, monoubiquitination, transcription perturbation",

author = "Zhuobin Liang and Fengshan Liang and Yaqun Teng and Xiaoyong Chen and Jingchun Liu and Simonne Longerich and Timsi Rao and Green, {Allison M.} and Collins, {Natalie B.} and Yong Xiong and Li Lan and Patrick Sung and Kupfer, {Gary M.}",

note = "Publisher Copyright: {\textcopyright} 2018 The Authors",

year = "2019",

month = jan,

day = "15",

doi = "10.1016/j.celrep.2018.12.084",

language = "English (US)",

volume = "26",

pages = "564--572.e5",

journal = "Cell Reports",

issn = "2211-1247",

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TY - JOUR

T1 - Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

AU - Liang, Zhuobin

AU - Liang, Fengshan

AU - Teng, Yaqun

AU - Chen, Xiaoyong

AU - Liu, Jingchun

AU - Longerich, Simonne

AU - Rao, Timsi

AU - Green, Allison M.

AU - Collins, Natalie B.

AU - Xiong, Yong

AU - Lan, Li

AU - Sung, Patrick

AU - Kupfer, Gary M.

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

AB - Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

KW - DNA damage

KW - FANCD2

KW - FANCI-FANCD2

KW - Fanconi anemia

KW - R-loop

KW - RNA

KW - monoubiquitination

KW - transcription perturbation

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U2 - 10.1016/j.celrep.2018.12.084

DO - 10.1016/j.celrep.2018.12.084

M3 - Article

C2 - 30650351

AN - SCOPUS:85059819767

SN - 2211-1247

VL - 26

SP - 564-572.e5

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Abstract

Keywords

ASJC Scopus subject areas

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