Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination

Zhuobin Liang, Fengshan Liang, Yaqun Teng, Xiaoyong Chen, Jingchun Liu, Simonne Longerich, Timsi Rao, Allison M. Green, Natalie B. Collins, Yong Xiong, Li Lan, Patrick Sung, Gary M. Kupfer

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Fanconi anemia pathway has a well-known role in the repair of DNA crosslinks, but its recently identified role in suppression of co-transcriptional R-loops remains elusive. Here, Liang et al. show that FANCI-FANCD2 has intrinsic RNA and R-loop binding activity and provide mechanistic insights into FA pathway activation upon transcription stress.

Original languageEnglish (US)
Pages (from-to)564-572.e5
JournalCell Reports
Volume26
Issue number3
DOIs
StatePublished - Jan 15 2019

Keywords

  • DNA damage
  • FANCD2
  • FANCI-FANCD2
  • Fanconi anemia
  • R-loop
  • RNA
  • monoubiquitination
  • transcription perturbation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Liang, Z., Liang, F., Teng, Y., Chen, X., Liu, J., Longerich, S., Rao, T., Green, A. M., Collins, N. B., Xiong, Y., Lan, L., Sung, P., & Kupfer, G. M. (2019). Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination. Cell Reports, 26(3), 564-572.e5. https://doi.org/10.1016/j.celrep.2018.12.084