Binding of C‐terminal segments of neuropeptide Y to chicken brain

MICHAEL O. PERLMAN, JANET M. PERLMAN, MARTIN L. ADAMO, ROBERT L. HAZELWOOD, DOUGLAS F. DYCKES

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The C‐terminal pentapeptide amide segment of neuropeptide Y (NPY) binds specifically to chicken brain membrane preparations. The contribution of each residue of the C‐terminus to this binding has been investigated through the synthesis and evaluation of a series of pentapeptide analogs. The binding of these molecules is strongly dependent on the presence of certain functional groups, in particular the guanidinium group of Arg‐35 and the C‐terminal aromatic amide function. The significance of these results for the binding to chicken brain tissue of NPY, pancreatic polypeptide and other potentially related neuropeptides is discussed.

Original languageEnglish (US)
Pages (from-to)153-162
Number of pages10
JournalInternational Journal of Peptide and Protein Research
Volume30
Issue number2
DOIs
StatePublished - Aug 1987
Externally publishedYes

Keywords

  • FMRF amide
  • Fmoc amino acids
  • LPLRF amide
  • brain binding studies
  • neuropeptide Y (NPY)
  • pancreatic polypeptide (PP)
  • solid phase synthesis

ASJC Scopus subject areas

  • Biochemistry

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