Binding of 2-[125I]melatonin by rat thymus membranes during postnatal development

A. Martin-Cacao, M. A. Lopez-Gonzalez, R. J. Reiter, J. R. Calvo, J. M. Guerrero

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Previously, we have demonstrated the presence of melatonin binding sites in thymus membranes of adult rats. In this paper, we show that the binding of melatonin by thymus membranes changes during postnatal development. Maximum binding was observed in newborn rats; thereafter, binding decreased progressively during the first weeks of life and exhibited the lowest values in adult animals. Stoichiometric studies showed that the decrease in melatonin binding was due to changes in the binding capacity (2.5-fold) rather than to changes in the affinity of the receptor for the ligand. The results suggest a physiological role of melatonin in regulating thymus activity early during postnatal development.

Original languageEnglish (US)
Pages (from-to)59-63
Number of pages5
JournalImmunology Letters
Volume36
Issue number1
DOIs
StatePublished - Apr 1993

Keywords

  • Immune system
  • Melatonin
  • Pineal
  • Thymus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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