Binding of 2-[125I]melatonin by rat thymus membranes during postnatal development

A. Martin-Cacao; M. A. Lopez-Gonzalez; R. J. Reiter; J. R. Calvo; J. M. Guerrero

doi:10.1016/0165-2478(93)90069-E

Binding of 2-[¹²⁵I]melatonin by rat thymus membranes during postnatal development

A. Martin-Cacao, M. A. Lopez-Gonzalez, R. J. Reiter, J. R. Calvo, J. M. Guerrero

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Previously, we have demonstrated the presence of melatonin binding sites in thymus membranes of adult rats. In this paper, we show that the binding of melatonin by thymus membranes changes during postnatal development. Maximum binding was observed in newborn rats; thereafter, binding decreased progressively during the first weeks of life and exhibited the lowest values in adult animals. Stoichiometric studies showed that the decrease in melatonin binding was due to changes in the binding capacity (2.5-fold) rather than to changes in the affinity of the receptor for the ligand. The results suggest a physiological role of melatonin in regulating thymus activity early during postnatal development.

Original language	English (US)
Pages (from-to)	59-63
Number of pages	5
Journal	Immunology Letters
Volume	36
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(93)90069-E
State	Published - Apr 1993

Keywords

Immune system
Melatonin
Pineal
Thymus

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/0165-2478(93)90069-E

Cite this

@article{a9fe2542eb63428ab9e9a4d85d566773,

title = "Binding of 2-[125I]melatonin by rat thymus membranes during postnatal development",

abstract = "Previously, we have demonstrated the presence of melatonin binding sites in thymus membranes of adult rats. In this paper, we show that the binding of melatonin by thymus membranes changes during postnatal development. Maximum binding was observed in newborn rats; thereafter, binding decreased progressively during the first weeks of life and exhibited the lowest values in adult animals. Stoichiometric studies showed that the decrease in melatonin binding was due to changes in the binding capacity (2.5-fold) rather than to changes in the affinity of the receptor for the ligand. The results suggest a physiological role of melatonin in regulating thymus activity early during postnatal development.",

keywords = "Immune system, Melatonin, Pineal, Thymus",

author = "A. Martin-Cacao and Lopez-Gonzalez, {M. A.} and Reiter, {R. J.} and Calvo, {J. R.} and Guerrero, {J. M.}",

note = "Funding Information: Supported by grants from Comision lntermi-nisterial de Ciencia y Tecnologia (PM91-0616) and Spain-USA Joint Committee. J.M.G. was supported by a fellowship of the NATO Scientific Program.",

year = "1993",

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doi = "10.1016/0165-2478(93)90069-E",

language = "English (US)",

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journal = "Immunology Letters",

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T1 - Binding of 2-[125I]melatonin by rat thymus membranes during postnatal development

AU - Martin-Cacao, A.

AU - Lopez-Gonzalez, M. A.

AU - Reiter, R. J.

AU - Calvo, J. R.

AU - Guerrero, J. M.

N1 - Funding Information: Supported by grants from Comision lntermi-nisterial de Ciencia y Tecnologia (PM91-0616) and Spain-USA Joint Committee. J.M.G. was supported by a fellowship of the NATO Scientific Program.

PY - 1993/4

Y1 - 1993/4

N2 - Previously, we have demonstrated the presence of melatonin binding sites in thymus membranes of adult rats. In this paper, we show that the binding of melatonin by thymus membranes changes during postnatal development. Maximum binding was observed in newborn rats; thereafter, binding decreased progressively during the first weeks of life and exhibited the lowest values in adult animals. Stoichiometric studies showed that the decrease in melatonin binding was due to changes in the binding capacity (2.5-fold) rather than to changes in the affinity of the receptor for the ligand. The results suggest a physiological role of melatonin in regulating thymus activity early during postnatal development.

AB - Previously, we have demonstrated the presence of melatonin binding sites in thymus membranes of adult rats. In this paper, we show that the binding of melatonin by thymus membranes changes during postnatal development. Maximum binding was observed in newborn rats; thereafter, binding decreased progressively during the first weeks of life and exhibited the lowest values in adult animals. Stoichiometric studies showed that the decrease in melatonin binding was due to changes in the binding capacity (2.5-fold) rather than to changes in the affinity of the receptor for the ligand. The results suggest a physiological role of melatonin in regulating thymus activity early during postnatal development.

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KW - Melatonin

KW - Pineal

KW - Thymus

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