Bilateral conjunctival pediatric follicular lymphoma

Alia Nazarullah, Luke Dietz, Kenneth Wright, Serhan Alkan, Qin Huang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Follicular lymphoma (FL) is the most common type of B cell non-Hodgkin lymphoma in Western counties. FL is usually seen in adults and is very uncommon in pediatric population. Pediatric follicular lymphoma (PFL) is a rare indolent lymphoma characteristically seen in pediatric population, usually involving cervical lymph nodes, Waldeyer ring, and testis. They pose significant diagnostic challenges due to morphologic overlap with much more common florid follicular hyperplasia and lack of typical t(14;18)IgH/BCL2 fusion and BCL-2 protein expression. We present the case of a 10-year-old male with bilateral conjunctival nodules, showing characteristic morphologic and immunophenotypic features of PFL with demonstrated clonal B cell immunoglobulin heavy chain gene rearrangement. Of note, the neoplastic cells expressed MUM1, MYC, and IgM, suggestive of a different disease pathogenesis from adult FL.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalJournal of Hematopathology
Volume9
Issue number1
DOIs
StatePublished - Mar 1 2016

Keywords

  • Bilateral
  • Conjunctival
  • Follicular
  • Lymphoma
  • Pediatric

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Hematology

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