Bidirectional placental transfer of glucose and its turnover in fetal and maternal sheep

Rajen S. Anand, Mark A. Sperling, Supriya Ganguli, Peter W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Glucose biokinetics were assessed simultaneously in the pregnant ewe and its fetus by a primed constant infusion of 2-sH glucose and U-14C glucose. Late in gestation fetal glucose turnover was 27.3 ± 3.7 mg/min; expressed in terms of fetal weight this is 6 to 10 mgAg/min. In the fed state the results indicated that all of the fetal glucose turnover was derived from the mother via placental transfer and there was no evidence that the fetus was capable of glucose production. Maternal glucose turnover was 145.6 ± 9.3 mg/min (2.8 mgAg/min). There was a significant amount of glucose (16.3 ± 2.3 mg/min) transferred from the fetus to the mother. This feto-matemal transfer of glucose accounted for 11% of the maternal glucose turnover and approximately 50% of the total glucose coming to the fetus from the mother. This study provides the first in vivo simultaneous quantification of the bidirectional glucose transfer across the placenta.

Original languageEnglish (US)
Pages (from-to)783-787
Number of pages5
JournalPediatric Research
Issue number6
StatePublished - Jun 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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