Bicarbonate reabsorption in the papillary collecting duct: Effect of acetazolamide

R. M.A. Richardson, R. T. Kunau

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20 Scopus citations

Abstract

The present study was designed to characterize bicarbonate (total CO2) reabsorption in the papillary collecting duct of the kidney of the Munich-Wistar rat when total CO2 delivery to this segment was increased by the systemic infusion of a bicarbonate-rich solution. Additional studies examined the effect of the systemic administration of acetazolamide, a carbonic anhydrase inhibitor, on total CO2 reabsorption. Employing free-flow micropuncture techniques, tubular fluid samples were obtained from the base and tip of the exposed papilla and subsequently analyzed for total CO2 and inulin. Total CO2 reabsorption increased in a linear fashion, approximately 34% of that delivered to the base, as total CO2 delivery increased from 3 to 20% of the filtered load. When examined at comparable absolute rates of total CO2 delivery (μmol/min) to the papillary collecting duct, acetazolamide administration resulted in marked inhibition of total CO2 reabsorption. The results of these studies suggest that the papillary collecting duct of the rat kidney possesses a significant capacity for reabsorption of total CO2 and that this reabsorption is diminished by the administration of acetazolamide.

Original languageEnglish (US)
Pages (from-to)F74-F80
JournalAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Physiology

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