Bicarbonate reabsorption in the papillary collecting duct: Effect of acetazolamide

R. M A Richardson, R. T. Kunau

Research output: Chapter in Book/Report/Conference proceedingChapter

20 Citations (Scopus)

Abstract

The present study was designed to characterize bicarbonate (total CO2) reabsorption in the papillary collecting duct of the kidney of the Munich-Wistar rat when total CO2 delivery to this segment was increased by the systemic infusion of a bicarbonate-rich solution. Additional studies examined the effect of the systemic administration of acetazolamide, a carbonic anhydrase inhibitor, on total CO2 reabsorption. Employing free-flow micropuncture techniques, tubular fluid samples were obtained from the base and tip of the exposed papilla and subsequently analyzed for total CO2 and inulin. Total CO2 reabsorption increased in a linear fashion, approximately 34% of that delivered to the base, as total CO2 delivery increased from 3 to 20% of the filtered load. When examined at comparable absolute rates of total CO2 delivery (μmol/min) to the papillary collecting duct, acetazolamide administration resulted in marked inhibition of total CO2 reabsorption. The results of these studies suggest that the papillary collecting duct of the rat kidney possesses a significant capacity for reabsorption of total CO2 and that this reabsorption is diminished by the administration of acetazolamide.

Original languageEnglish (US)
Title of host publicationAmerican Journal of Physiology - Renal Fluid and Electrolyte Physiology
Volume12
Edition1
StatePublished - 1982

Fingerprint

Acetazolamide
Bicarbonates
Collecting Kidney Tubules
Carbonic Anhydrase Inhibitors
Inulin
Punctures
Wistar Rats

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Richardson, R. M. A., & Kunau, R. T. (1982). Bicarbonate reabsorption in the papillary collecting duct: Effect of acetazolamide. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology (1 ed., Vol. 12)

Bicarbonate reabsorption in the papillary collecting duct : Effect of acetazolamide. / Richardson, R. M A; Kunau, R. T.

American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 12 1. ed. 1982.

Research output: Chapter in Book/Report/Conference proceedingChapter

Richardson, RMA & Kunau, RT 1982, Bicarbonate reabsorption in the papillary collecting duct: Effect of acetazolamide. in American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1 edn, vol. 12.
Richardson RMA, Kunau RT. Bicarbonate reabsorption in the papillary collecting duct: Effect of acetazolamide. In American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 1 ed. Vol. 12. 1982
Richardson, R. M A ; Kunau, R. T. / Bicarbonate reabsorption in the papillary collecting duct : Effect of acetazolamide. American Journal of Physiology - Renal Fluid and Electrolyte Physiology. Vol. 12 1. ed. 1982.
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