Bicarbonate reabsorption in the papillary collecting duct: effect of acetazolamide.

R. M. Richardson, R. T. Kunau

Research output: Contribution to journalArticle

Abstract

The present study was designed to characterize bicarbonate (total CO2) reabsorption in the papillary collecting duct of the kidney of the Munich-Wistar rat when total CO2 delivery to this segment was increased by the systemic infusion of a bicarbonate-rich solution. Additional studies examined the effect of the systemic administration of acetazolamide, a carbonic anhydrase inhibitor, on total CO2 reabsorption. Employing free-flow micropuncture techniques, tubular fluid samples were obtained from the base and tip of the exposed papilla and subsequently analyzed for total CO2 and inulin. Total CO2 reabsorption increased in a linear fashion, approximating 34% of that delivered to the base, as total CO2 delivery increased from 3 to 20% of the filtered load. When examined at comparable absolute rates of total CO2 delivery (mumol/min) to the papillary collecting duct, acetazolamide administration resulted in marked inhibition of total CO2 reabsorption. The results of these studies suggest that the papillary collecting duct of the rat kidney possesses a significant capacity for reabsorption of total CO2 and that this reabsorption is diminished by the administration of acetazolamide.

Original languageEnglish (US)
JournalThe American journal of physiology
Volume243
Issue number1
StatePublished - Jul 1982
Externally publishedYes

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Acetazolamide
Bicarbonates
Collecting Kidney Tubules
Carbonic Anhydrase Inhibitors
Inulin
Punctures
Wistar Rats

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bicarbonate reabsorption in the papillary collecting duct : effect of acetazolamide. / Richardson, R. M.; Kunau, R. T.

In: The American journal of physiology, Vol. 243, No. 1, 07.1982.

Research output: Contribution to journalArticle

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