TY - JOUR
T1 - Beyond the single study
T2 - Function/location metanalysis in cognitive neuroimaging
AU - Fox, Peter T.
AU - Parsons, Lawrence M.
AU - Lancaster, Jack L.
N1 - Funding Information:
We thank Lacey Rainey, Scott McGinnis and Shawn Mikicen for retrieving and pre-reviewing the literature reviewed here, for coding and entering all brain-mapping studies into the BrainMap @ database, and for creating the illustrations for this manuscript. This work was supported by the Human Frontier Science Program, the Human Brain Project, the Mind Science Foundation, the EJLB Foundation, and the State of Texas.
PY - 1998/4
Y1 - 1998/4
N2 - Cognitive neuroimaging maps the brain locations of mental operations. This process is iterative, as no single study can fully characterize a mental operation or its brain location. This iterative discovery process, in combination with the location-reporting standard (i.e. spatial coordinates) of the cognitive neuroimaging community, has engendered a new form of metanalysis. Response locations from multiple studies have been analyzed collectively so as to better describe the spatial distribution of brain activations, with promising results. New hypotheses regarding elementary mental operations and their respective brain locations are being generated and refined via metanalysis. These hypotheses are being tested and confirmed by subsequent, prospective experiments. Function/location metanalysis is an important new tool for hypothesis generation in cognitive neuroimagjng. This form of metanalysis is fundamentally different from the effect-size metanalyses prevalent in other literatures, with unique advantages and challenges.
AB - Cognitive neuroimaging maps the brain locations of mental operations. This process is iterative, as no single study can fully characterize a mental operation or its brain location. This iterative discovery process, in combination with the location-reporting standard (i.e. spatial coordinates) of the cognitive neuroimaging community, has engendered a new form of metanalysis. Response locations from multiple studies have been analyzed collectively so as to better describe the spatial distribution of brain activations, with promising results. New hypotheses regarding elementary mental operations and their respective brain locations are being generated and refined via metanalysis. These hypotheses are being tested and confirmed by subsequent, prospective experiments. Function/location metanalysis is an important new tool for hypothesis generation in cognitive neuroimagjng. This form of metanalysis is fundamentally different from the effect-size metanalyses prevalent in other literatures, with unique advantages and challenges.
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U2 - 10.1016/S0959-4388(98)80138-4
DO - 10.1016/S0959-4388(98)80138-4
M3 - Article
C2 - 9635200
AN - SCOPUS:0032052695
SN - 0959-4388
VL - 8
SP - 178
EP - 187
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 2
ER -