Beyond genotype: Serotonin transporter epigenetic modification predicts human brain function

Yuliya S. Nikolova, Karestan C. Koenen, Sandro Galea, Chiou Miin Wang, Marianne L. Seney, Etienne Sibille, Douglas E. Williamson, Ahmad R. Hariri

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.

Original languageEnglish (US)
Pages (from-to)1153-1155
Number of pages3
JournalNature Neuroscience
Volume17
Issue number9
DOIs
StatePublished - Sep 1 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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