Benzodiazepines suppress the light response of retinal dopaminergic neurons in vivo

Cylia W. Kamp, William W. Morgan

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Sedative dosages of the benzodiazepine, diazepam (76 μmol/kg, i.p.), reduce the light-evoked increase in retinal dopamine turnover, while intraocular applications of the water-soluble benzodiazepine, flurazepam (0.50 or 1.0 μmol/eyeball), produce a dose-dependent suppression of light-enhanced dopamine synthesis. These results provide the first evidence that the benzodiazepines alter a physiologically important retinal response in vivo. They also suggest that some of the visual effects produced by the benzodiazepines may have an intraretinal locus of action.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalEuropean Journal of Pharmacology
Volume77
Issue number4
DOIs
StatePublished - Feb 5 1982

Keywords

  • Benzodiazepines
  • Diazepam
  • Flurazepam
  • Light response
  • Retina
  • Retinal dopamine neurons

ASJC Scopus subject areas

  • Pharmacology

Fingerprint

Dive into the research topics of 'Benzodiazepines suppress the light response of retinal dopaminergic neurons in vivo'. Together they form a unique fingerprint.

Cite this