Benzodiazepine and β-carboline modulation of GABA-stimulated 36Cl-influx in cultured spinal cord neurons

Paul F. Lehoullier, Maharaj K. Ticku

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

GABAA agonists stimulate 36Cl-influx in spinal cord cultured neurons in a concentration-dependent manner. This effect of GABAA receptor stimulation is enhanced by benzodiazepines like clonazepam, diazepam and flurazepam and attenuated by (+)bicuculline and picrotoxinin. The β-carbolines, methyl-6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate (DMCM) and propyl-β-carboline-3-carboxylate (β-CCPr) exhibited opposite effects, with DMCM attenuating, while β-CCPr potentiating GABA's effect. These results are consistent with the behavioral and electrophysiological effect of benzodiazepines and β-carbolines with GABA receptor complex.

Original languageEnglish (US)
Pages (from-to)235-238
Number of pages4
JournalEuropean Journal of Pharmacology
Volume135
Issue number2
DOIs
StatePublished - Mar 17 1987

Keywords

  • Cl-influx
  • Benzodiazepines
  • GABA
  • Spinal cord (cultured neurons)
  • β-Carbolines

ASJC Scopus subject areas

  • Pharmacology

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