Beneficial actions of melatonin in the management of viral infections

A new use for this "molecular handyman"?

Jose Antonio Boga, Ana Coto-Montes, Sergio A. Rosales-Corral, Dun Xian Tan, Russel J Reiter

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Melatonin (N-acetyl-5-methoxytryptamine) is a multifunctional signaling molecule that has a variety of important functions. Numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine. Clinical trials have shown that melatonin is efficient in preventing cell damage under acute (sepsis, asphyxia in newborns) and chronic states (metabolic and neurodegenerative diseases, cancer, inflammation, aging). The beneficial effects of melatonin can be explained by its properties as a potent antioxidant and antioxidant enzyme inducer, a regulator of apoptosis and a stimulator of immune functions. These effects support the use of melatonin in viral infections, which are often associated with inflammatory injury and increases in oxidative stress. In fact, melatonin has been used recently to treat several viral infections, which are summarized in this review. The role of melatonin in infections is also discussed herein.

Original languageEnglish (US)
Pages (from-to)323-338
Number of pages16
JournalReviews in Medical Virology
Volume22
Issue number5
DOIs
StatePublished - Sep 2012

Fingerprint

Virus Diseases
Melatonin
Antioxidants
5-Methoxytryptamine
Clinical Trials
Asphyxia
Metabolic Diseases
Neurodegenerative Diseases
Sepsis
Oxidative Stress
Medicine
Apoptosis
Inflammation
Wounds and Injuries
Enzymes
Infection
Neoplasms

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Beneficial actions of melatonin in the management of viral infections : A new use for this "molecular handyman"? / Boga, Jose Antonio; Coto-Montes, Ana; Rosales-Corral, Sergio A.; Tan, Dun Xian; Reiter, Russel J.

In: Reviews in Medical Virology, Vol. 22, No. 5, 09.2012, p. 323-338.

Research output: Contribution to journalArticle

Boga, Jose Antonio ; Coto-Montes, Ana ; Rosales-Corral, Sergio A. ; Tan, Dun Xian ; Reiter, Russel J. / Beneficial actions of melatonin in the management of viral infections : A new use for this "molecular handyman"?. In: Reviews in Medical Virology. 2012 ; Vol. 22, No. 5. pp. 323-338.
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