@article{f44730364746457491a5d87d975dc3fc,
title = "Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium",
abstract = "The isolation and structure elucidation of belamide A from the marine cyanobacterium Symploca sp. is described. Belamide A is a highly methylated linear tetrapeptide with structural analogy to the important linear peptides dolastatins 10 and 15. Disruption of the microtubule network in A-10 cells was observed at 20 μM and displayed classic tubulin destabilizing antimitotic characteristics. The moderate cytotoxicity of belamide A (IC50 0.74 μM vs HCT-116 colon cancer line) provides new insights into structure-activity relationships for this drug class.",
keywords = "Dolastatins, Linear peptide, Marine natural products, Symploca sp.",
author = "Simmons, {T. Luke} and McPhail, {Kerry L.} and Eduardo Ortega-Barr{\'i}a and Mooberry, {Susan L.} and Gerwick, {William H.}",
note = "Funding Information: We thank H. Gross, for helpful suggestions with this investigation, particularly the NMR studies. Financial support was provided by the Fogarty International Center{\textquoteright}s International Cooperative Biodiversity Groups (ICBG) program in Panama (ICBG TW006634). High resolution and tandem MS data provided by J. Moore at the Environmental Health Sciences Mass Spectroscopy Facility (NIEHS grant P30 ES00210) and 600 MHz NMR data were acquired at the Biochemistry and Biophysics NMR facility, both at OSU. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",
year = "2006",
month = may,
day = "15",
doi = "10.1016/j.tetlet.2006.03.082",
language = "English (US)",
volume = "47",
pages = "3387--3390",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "20",
}