Behavioral pharmacology of antagonists at 5-HT2/5-HT1C receptors

Wouter Koek, Anne Jackson, Francis C. Colpaert

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


The possible implication of 5-HT2 receptors in CNS disorders such as schizophrenia, anxiety and depression suggests that 5-HT2 antagonists may be useful in the treatment of these disorders. The present review examines behavioral procedures used to characterize 5-HT2 antagonist properties of compounds and behavioral models of clinical activity in which 5-HT2 antagonists have been reported to be active. The pharmacological profile of 5-HT2 receptors in part resembles that of 5-HT1C receptors. Responses that have been proposed to involve the activation of 5-HT1C receptors are examined for their usefulness to detect 5-HT1C antagonist properties of compounds; these responses would help to differentiate 5-HT2 from 5-HT1C antagonist activity.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalNeuroscience and Biobehavioral Reviews
Issue number1
StatePublished - 1992
Externally publishedYes


  • 5-HT
  • 5-HT
  • Antagonists
  • DRL 72
  • Flat body posture Drug discrimination
  • Forepaw treading
  • Head-twitches
  • Pigeon conflict
  • Receptors

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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