Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat

John L. Falk, Herman H. Samson, Gail Winger

Research output: Contribution to journalArticlepeer-review

204 Scopus citations

Abstract

Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grains of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administration of an aqueous ethanol solution, resulting in unequivocal physical dependence, approximates a model of human alcoholism.

Original languageEnglish (US)
Pages (from-to)811-813
Number of pages3
JournalScience
Volume177
Issue number4051
DOIs
StatePublished - Jan 1 1972
Externally publishedYes

ASJC Scopus subject areas

  • General

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