Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat

John L. Falk; Herman H. Samson; Gail Winger

doi:10.1126/science.177.4051.811

Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat

John L. Falk, Herman H. Samson, Gail Winger

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grains of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administration of an aqueous ethanol solution, resulting in unequivocal physical dependence, approximates a model of human alcoholism.

Original language	English (US)
Pages (from-to)	811-813
Number of pages	3
Journal	Science
Volume	177
Issue number	4051
DOIs	https://doi.org/10.1126/science.177.4051.811
State	Published - Jan 1 1972
Externally published	Yes

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