Abstract
Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grains of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administration of an aqueous ethanol solution, resulting in unequivocal physical dependence, approximates a model of human alcoholism.
Original language | English (US) |
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Pages (from-to) | 811-813 |
Number of pages | 3 |
Journal | Science |
Volume | 177 |
Issue number | 4051 |
DOIs | |
State | Published - 1972 |
Externally published | Yes |
ASJC Scopus subject areas
- General