Behavioral investigation of mice with experimental autoimmune encephalomyelitis.

David Henrique Rodrigues, Márcia de Carvalho Vilela, Norinne Lacerda-Queiroz, Aline Silva de Miranda, Larissa Fonseca da Cunha Sousa, Helton José dos Reis, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG(35-55) model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG(35-55) are probably subtle or absent.

Original languageEnglish (US)
Pages (from-to)938-942
Number of pages5
JournalArquivos de neuro-psiquiatria
Volume69
Issue number6
DOIs
StatePublished - Dec 2011
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

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