TY - JOUR
T1 - Behavioral investigation of mice with experimental autoimmune encephalomyelitis.
AU - Rodrigues, David Henrique
AU - Vilela, Márcia de Carvalho
AU - Lacerda-Queiroz, Norinne
AU - Miranda, Aline Silva de
AU - Sousa, Larissa Fonseca da Cunha
AU - Reis, Helton José dos
AU - Teixeira, Antônio Lúcio
PY - 2011/12
Y1 - 2011/12
N2 - Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG(35-55) model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG(35-55) are probably subtle or absent.
AB - Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis. Experimental autoimmune encephalomyelitis (EAE) is considered to be a model of multiple sclerosis and mimics the main features of the disease, such as demyelination and motor impairment. In this work, we aimed to study behavioral parameters in animals with EAE using the MOG(35-55) model in C57BL/6 mice. We analyzed memory and anxiety in animals using the elevated plus maze, the step down inhibitory avoidance task and the memory recognition test. No differences in any tests were found when comparing controls and animals induced with EAE. Therefore, we conclude that behavioral changes in animals with EAE induced with MOG(35-55) are probably subtle or absent.
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U2 - 10.1590/s0004-282x2011000700018
DO - 10.1590/s0004-282x2011000700018
M3 - Article
C2 - 22297884
AN - SCOPUS:84866160667
SN - 0004-282X
VL - 69
SP - 938
EP - 942
JO - Arquivos de neuro-psiquiatria
JF - Arquivos de neuro-psiquiatria
IS - 6
ER -