Behavioral effects of amphetamine in streptozotocin-treated rats

Rajkumar J. Sevak, Wouter Koek, Lynette C. Daws, William Anthony Owens, Aurelio Galli, Charles P. France

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Experimentally-induced diabetes can modify the behavioral and neurochemical effects of drugs acting on dopamine systems, possibly through insulin-related regulation of dopamine transporter activity. In this study, several behavioral procedures were used to examine possible changes in sensitivity to amphetamine and other drugs in rats rendered diabetic by a single injection of streptozotocin. Conditioned place preference developed to food (Froot Loops®) in both control and diabetic rats, demonstrating that conditioned place preference with tactile stimuli can occur in streptozotocin-treated rats. Baseline locomotion was lower in streptozotocin-treated as compared to control rats, although amphetamine significantly increased locomotion in all rats. Conditioned place preference developed to amphetamine regardless of whether rats had received streptozotocin or saline. A second study compared the potency of drugs to decrease lever pressing maintained by food, before and after streptozotocin treatment. Gamma-hydroxybutyrate and amphetamine were less potent after streptozotocin while the potency of raclopride, quinpirole, ketamine, haloperidol and cocaine was not significantly changed by streptozotocin. While markedly affecting locomotion, body weight and blood glucose, streptozotocin only modestly affected sensitivity to the behavioral effects of amphetamine and other drugs; these results fail to confirm previous reports of decreased behavioral actions of stimulants in diabetic rats.

Original languageEnglish (US)
Pages (from-to)105-112
Number of pages8
JournalEuropean Journal of Pharmacology
Volume581
Issue number1-2
DOIs
StatePublished - Feb 26 2008

Keywords

  • Amphetamine
  • Conditioned place preference
  • Dopamine transporter
  • Locomotion
  • Streptozotocin

ASJC Scopus subject areas

  • Pharmacology

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