Behavioral characterization of opioid mixed agonist-antagonists

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14 Scopus citations

Abstract

The effects of agonists and partial agonists of both mu and kappa receptor systems are described in several behavioral tests in rhesus monkeys. Procedures measuring drug discrimination, drug self-administration, drug dependence, and drug-induced analgesia are differentially sensitive to the agonist and antagonist effects of various opioids. The sensitivity of each of the procedures may be modified by altering behavioral parameters or dose of drug used to establish the behavioral effect.

Original languageEnglish (US)
Pages (from-to)303-315
Number of pages13
JournalDrug and Alcohol Dependence
Volume20
Issue number4
DOIs
StatePublished - Dec 1987

Keywords

  • Analgesia
  • Drug-discrimination
  • Opioids
  • Physiological dependence
  • Rhesus monkey
  • Self-administration

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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