Behavioral characterization of opioid mixed agonist-antagonists

James H. Woods; Gail Winger

doi:10.1016/0376-8716(87)90004-4

Behavioral characterization of opioid mixed agonist-antagonists

James H. Woods, Gail Winger

Pharmacology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The effects of agonists and partial agonists of both mu and kappa receptor systems are described in several behavioral tests in rhesus monkeys. Procedures measuring drug discrimination, drug self-administration, drug dependence, and drug-induced analgesia are differentially sensitive to the agonist and antagonist effects of various opioids. The sensitivity of each of the procedures may be modified by altering behavioral parameters or dose of drug used to establish the behavioral effect.

Original language	English (US)
Pages (from-to)	303-315
Number of pages	13
Journal	Drug and Alcohol Dependence
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/0376-8716(87)90004-4
State	Published - Dec 1987

Keywords

Analgesia
Drug-discrimination
Opioids
Physiological dependence
Rhesus monkey
Self-administration

ASJC Scopus subject areas

Toxicology
Pharmacology
Psychiatry and Mental health
Pharmacology (medical)

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title = "Behavioral characterization of opioid mixed agonist-antagonists",

abstract = "The effects of agonists and partial agonists of both mu and kappa receptor systems are described in several behavioral tests in rhesus monkeys. Procedures measuring drug discrimination, drug self-administration, drug dependence, and drug-induced analgesia are differentially sensitive to the agonist and antagonist effects of various opioids. The sensitivity of each of the procedures may be modified by altering behavioral parameters or dose of drug used to establish the behavioral effect.",

keywords = "Analgesia, Drug-discrimination, Opioids, Physiological dependence, Rhesus monkey, Self-administration",

author = "Woods, {James H.} and Gail Winger",

note = "Funding Information: The original research described was supported by USPHS grants DA-00154 and DA-00254. We thank A. Bertalmio and W. Koek for careful reading of the manuscript.",

year = "1987",

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AU - Woods, James H.

AU - Winger, Gail

N1 - Funding Information: The original research described was supported by USPHS grants DA-00154 and DA-00254. We thank A. Bertalmio and W. Koek for careful reading of the manuscript.

PY - 1987/12

Y1 - 1987/12

N2 - The effects of agonists and partial agonists of both mu and kappa receptor systems are described in several behavioral tests in rhesus monkeys. Procedures measuring drug discrimination, drug self-administration, drug dependence, and drug-induced analgesia are differentially sensitive to the agonist and antagonist effects of various opioids. The sensitivity of each of the procedures may be modified by altering behavioral parameters or dose of drug used to establish the behavioral effect.

AB - The effects of agonists and partial agonists of both mu and kappa receptor systems are described in several behavioral tests in rhesus monkeys. Procedures measuring drug discrimination, drug self-administration, drug dependence, and drug-induced analgesia are differentially sensitive to the agonist and antagonist effects of various opioids. The sensitivity of each of the procedures may be modified by altering behavioral parameters or dose of drug used to establish the behavioral effect.

KW - Analgesia

KW - Drug-discrimination

KW - Opioids

KW - Physiological dependence

KW - Rhesus monkey

KW - Self-administration

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