Behavioral and electrophysiological analysis of Ca-activated K-channel transgenes in drosophila

Nigel S. Atkinson, Robert Brenner, Rudi A. Bohm, Joyce Y. Yu, Jennette L. Wilbur

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The slowpoke gene of Drosophila melanogaster encodes a Ca-activated K channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut. The gene produces a large number of alternative products using tissue-specific transcriptional promoters and alternative mRNA splicing. We have described in great depth how transcription is regulated and are now cataloging the tissue-specificity of different splice variants. It is believed that the diversity of products serves to tailor channel attributes to the needs of specific tissues. Electrophysiological and behavioral assays indicate that at least some of these products produce channels with distinct properties.

Original languageEnglish (US)
Pages (from-to)296-305
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume860
DOIs
Publication statusPublished - Jan 1 1998

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ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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