Behavioral and biochemical studies in monkeys made hemiparkinsonian by MPTP

Barbara A. Brooks, Eduardo Eidelberg, William W. Morgan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Monkeys were required to press a lever rapidly for food, using either the right or the left hand. After stable baseline performance was established, MPTP (N-methyl-4-phenyl-2,3,5,6-tetrahydropyridine) was injected into the internal carotid of one side via a transfemoral catheter. The onset and time course of clinically severe, Parkinson-like symptoms were paralleled by a significant decrease of bar-pressing activity in the side contralateral to injection, while the forelimb in the unaffected side continued normal pressing. The unilaterality of effects was confirmed biochemically after sacrifice by a 95% drop in striatal dopamine (DA) levels of the injected compared to the uninjected hemisphere. The results show that hemiparkinsonism achieved by carotid injection is very stable; that normal motor behavior is maintained on the unaffected side and that goal-achieving strategies remain active, but that the affected side is unable to execute the task unless extrinsic levodopa is provided.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalBrain Research
Issue number1-2
StatePublished - Sep 1 1987


  • Bar pressing
  • Hemiparkinsonism
  • Monkey model
  • N-Methyl-4-phenyl-2,3,5,6-tetrahydropyridine (MPTP)

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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