Abstract
BCL1 is a transplantable murine B-cell leukemia that closely resembles human prolymphocytic leukemia (PLL). Syngeneic mice injected with BCL1 cells develop massively enlarged spleens followed by leukemia. Splenectomy performed either prior to BCL1 transplantation or prior to the leukemic phase of transplanted BCL1 results in a markedly altered clinical syndrome: the onset of leukemia is delayed by about 2 months; the leukemia is low-grade; and the lymph nodes, which are not prominently involved in leukemic animals with intact spleens, are massively infiltrated in the splenectoized transplant recipient. The imunologic phenotype of the BCL1 cell is not altered by splenectomy and thus does not appear to account for the altered tissue distribution of BCL1 in the splenectomized host. However, the results indicates a striking dependence of BCL1 on microenvironmental influence of the host lymphoid tissues.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 295-305 |
| Number of pages | 11 |
| Journal | American Journal of Pathology |
| Volume | 105 |
| Issue number | 3 |
| State | Published - 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pathology and Forensic Medicine
Cite this
BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution. / Muirhead, M. J.; Isakson, P. C.; Krolick, Keith A.
In: American Journal of Pathology, Vol. 105, No. 3, 1981, p. 295-305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution
AU - Muirhead, M. J.
AU - Isakson, P. C.
AU - Krolick, Keith A
PY - 1981
Y1 - 1981
N2 - BCL1 is a transplantable murine B-cell leukemia that closely resembles human prolymphocytic leukemia (PLL). Syngeneic mice injected with BCL1 cells develop massively enlarged spleens followed by leukemia. Splenectomy performed either prior to BCL1 transplantation or prior to the leukemic phase of transplanted BCL1 results in a markedly altered clinical syndrome: the onset of leukemia is delayed by about 2 months; the leukemia is low-grade; and the lymph nodes, which are not prominently involved in leukemic animals with intact spleens, are massively infiltrated in the splenectoized transplant recipient. The imunologic phenotype of the BCL1 cell is not altered by splenectomy and thus does not appear to account for the altered tissue distribution of BCL1 in the splenectomized host. However, the results indicates a striking dependence of BCL1 on microenvironmental influence of the host lymphoid tissues.
AB - BCL1 is a transplantable murine B-cell leukemia that closely resembles human prolymphocytic leukemia (PLL). Syngeneic mice injected with BCL1 cells develop massively enlarged spleens followed by leukemia. Splenectomy performed either prior to BCL1 transplantation or prior to the leukemic phase of transplanted BCL1 results in a markedly altered clinical syndrome: the onset of leukemia is delayed by about 2 months; the leukemia is low-grade; and the lymph nodes, which are not prominently involved in leukemic animals with intact spleens, are massively infiltrated in the splenectoized transplant recipient. The imunologic phenotype of the BCL1 cell is not altered by splenectomy and thus does not appear to account for the altered tissue distribution of BCL1 in the splenectomized host. However, the results indicates a striking dependence of BCL1 on microenvironmental influence of the host lymphoid tissues.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019730611&partnerID=8YFLogxK
M3 - Article
C2 - 7032308
AN - SCOPUS:0019730611
VL - 105
SP - 295
EP - 305
JO - American Journal of Pathology
JF - American Journal of Pathology
SN - 0002-9440
IS - 3
ER -