BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution

M. J. Muirhead, P. C. Isakson, Keith A Krolick

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BCL1 is a transplantable murine B-cell leukemia that closely resembles human prolymphocytic leukemia (PLL). Syngeneic mice injected with BCL1 cells develop massively enlarged spleens followed by leukemia. Splenectomy performed either prior to BCL1 transplantation or prior to the leukemic phase of transplanted BCL1 results in a markedly altered clinical syndrome: the onset of leukemia is delayed by about 2 months; the leukemia is low-grade; and the lymph nodes, which are not prominently involved in leukemic animals with intact spleens, are massively infiltrated in the splenectoized transplant recipient. The imunologic phenotype of the BCL1 cell is not altered by splenectomy and thus does not appear to account for the altered tissue distribution of BCL1 in the splenectomized host. However, the results indicates a striking dependence of BCL1 on microenvironmental influence of the host lymphoid tissues.

Original languageEnglish (US)
Pages (from-to)295-305
Number of pages11
JournalAmerican Journal of Pathology
Volume105
Issue number3
StatePublished - 1981
Externally publishedYes

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Prolymphocytic Leukemia
Splenectomy
Leukemia
Growth
B-Cell Leukemia
Splenomegaly
Lymphoid Tissue
Tissue Distribution
Spleen
Transplantation
Lymph Nodes
Phenotype

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

BCL1, a murine model of prolymphocytic leukemia. I. Effect of splenectomy on growth kinetics and organ distribution. / Muirhead, M. J.; Isakson, P. C.; Krolick, Keith A.

In: American Journal of Pathology, Vol. 105, No. 3, 1981, p. 295-305.

Research output: Contribution to journalArticle

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