Bcl-2 family expression in salivary glands from patients with primary Sjogren's syndrome: Involvement of Bax in salivary gland destruction

Liping Kong, Noriyoshi Ogawa, H. Stan McGuff, Toru Nakabayashi, Ken Mei Sakata, Reiji Masago, Norma Vela-Roch, Norman Talal, Howard Dang

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

To investigate the molecular mechanism of glandular parenchyma destruction in Sjogren's syndrome (SS), Bcl-2, Bax, Bcl-X, and Bak expression were studied. SS (n = 18) and control salivary glands (n = 6)were examined by immunohistochemistry. Apoptosis was assessed by in situ DNA nick end labeling. Infiltrating mononuclear cells in the SS salivary gland showed elevated Bcl-2. These mononuclear cells expressed increased Bax but did not undergo apoptosis. Both SS and control salivary gland ductal epithelial cells expressed Bcl-2, Bax, and Bcl-X. SS, but not normal, salivary gland acinar cells expressed Bax and underwent apoptosis. These results suggest that elevated Bax expression in SS salivary gland acinar cells may play an important role in the apoptotic pathway. In contrast, Bcl-2 expression in SS infiltrating mononuclear cells and ductal cells may contribute to their survival.

Original languageEnglish (US)
Pages (from-to)133-141
Number of pages9
JournalClinical Immunology and Immunopathology
Volume88
Issue number2
DOIs
StatePublished - Aug 1998

Keywords

  • Apoptosis
  • Bcl-2
  • Salivary glands
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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