Basics of polymeric scaffolds for tissue engineering

C. Mauli Agrawal, B. S. Janell Carter, Joo L. Ong

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


This review article argues the case that there is a need for careful scaffold science for successful tissue engineering. Polymeric scaffolds should possess certain essential properties. However, these properties are not independent of each other and thus the development of a scaffold requires an optimization process. The article reviews several scaffold fabrication processes to highlight the complexity of the field. Issues related to porosity, permeability, and the need for adequate diffusion characteristics are discussed. Several previous studies on the effects of mixing in bioreactors are reviewed. Lastly, surface modification techniques are presented. In particular, recent work related to glow discharge gas plasma modification of biodegradable polymers is discussed.

Original languageEnglish (US)
JournalJournal of ASTM International
Issue number9
StatePublished - Oct 1 2006


  • Biodegradable
  • Diffusion
  • Fabrication techniques
  • Permeability
  • Polymer
  • Porosity
  • Scaffold science
  • Surface modification
  • Surface properties
  • Tissue engineering

ASJC Scopus subject areas

  • Environmental Engineering
  • Materials Science(all)
  • Nuclear Energy and Engineering
  • Engineering(all)
  • Public Health, Environmental and Occupational Health


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