Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

Theresa A. Guise; Khalid S. Mohammad; Gregory Clines; Elizabeth G. Stebbins; Darren H. Wong; Linda S. Higgins; Robert Vessella; Eva Corey; Susan Padalecki; Larry Suva; John M. Chirgwin; Pearse; Roodman; Lipton; Clohisy; Weilbaecher; Smith

doi:10.1158/1078-0432.CCR-06-1007

Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

Theresa A. Guise, Khalid S. Mohammad, Gregory Clines, Elizabeth G. Stebbins, Darren H. Wong, Linda S. Higgins, Robert Vessella, Eva Corey, Susan Padalecki, Larry Suva, John M. Chirgwin, Pearse, Roodman, Lipton, Clohisy, Weilbaecher, Smith

Research output: Contribution to journal › Review article › peer-review

446 Scopus citations

Abstract

Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

Original language	English (US)
Pages (from-to)	6213s-6216s
Journal	Clinical Cancer Research
Volume	12
Issue number	20 PART 2
DOIs	https://doi.org/10.1158/1078-0432.CCR-06-1007
State	Published - Oct 15 2006
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1158/1078-0432.CCR-06-1007

Cite this

Guise, T. A., Mohammad, K. S., Clines, G., Stebbins, E. G., Wong, D. H., Higgins, L. S., Vessella, R., Corey, E., Padalecki, S., Suva, L., Chirgwin, J. M., Pearse, Roodman, Lipton, Clohisy, Weilbaecher, & Smith (2006). Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. Clinical Cancer Research, 12(20 PART 2), 6213s-6216s. https://doi.org/10.1158/1078-0432.CCR-06-1007

Guise, TA, Mohammad, KS, Clines, G, Stebbins, EG, Wong, DH, Higgins, LS, Vessella, R, Corey, E, Padalecki, S, Suva, L, Chirgwin, JM, Pearse, Roodman, Lipton, Clohisy, Weilbaecher & Smith 2006, 'Basic mechanisms responsible for osteolytic and osteoblastic bone metastases', Clinical Cancer Research, vol. 12, no. 20 PART 2, pp. 6213s-6216s. https://doi.org/10.1158/1078-0432.CCR-06-1007

@article{e4c22e02182b4fc085c875e41ff4dd61,

title = "Basic mechanisms responsible for osteolytic and osteoblastic bone metastases",

abstract = "Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.",

author = "Guise, {Theresa A.} and Mohammad, {Khalid S.} and Gregory Clines and Stebbins, {Elizabeth G.} and Wong, {Darren H.} and Higgins, {Linda S.} and Robert Vessella and Eva Corey and Susan Padalecki and Larry Suva and Chirgwin, {John M.} and Pearse and Roodman and Lipton and Clohisy and Weilbaecher and Smith",

year = "2006",

month = oct,

day = "15",

doi = "10.1158/1078-0432.CCR-06-1007",

language = "English (US)",

volume = "12",

pages = "6213s--6216s",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

number = "20 PART 2",

}

TY - JOUR

T1 - Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

AU - Guise, Theresa A.

AU - Mohammad, Khalid S.

AU - Clines, Gregory

AU - Stebbins, Elizabeth G.

AU - Wong, Darren H.

AU - Higgins, Linda S.

AU - Vessella, Robert

AU - Corey, Eva

AU - Padalecki, Susan

AU - Suva, Larry

AU - Chirgwin, John M.

AU - Pearse,

AU - Roodman,

AU - Lipton,

AU - Clohisy,

AU - Weilbaecher,

AU - Smith,

PY - 2006/10/15

Y1 - 2006/10/15

N2 - Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

AB - Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

UR - http://www.scopus.com/inward/record.url?scp=33750738067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750738067&partnerID=8YFLogxK

U2 - 10.1158/1078-0432.CCR-06-1007

DO - 10.1158/1078-0432.CCR-06-1007

M3 - Review article

C2 - 17062703

AN - SCOPUS:33750738067

SN - 1078-0432

VL - 12

SP - 6213s-6216s

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 20 PART 2

ER -

Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this