Basic mechanisms responsible for osteolytic and osteoblastic bone metastases

Theresa A. Guise, Khalid S. Mohammad, Gregory Clines, Elizabeth G. Stebbins, Darren H. Wong, Linda S. Higgins, Robert Vessella, Eva Corey, Susan Padalecki, Larry Suva, John M. Chirgwin, Pearse, Roodman, Lipton, Clohisy, Weilbaecher, Smith

Research output: Contribution to journalReview articlepeer-review

442 Scopus citations


Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum, and most patients will have evidence of both. The mechanisms responsible for tumor growth in bone are complex and involve tumor stimulation of the osteoclast and the osteoblast as well as the response of the bone microenvironment. Furthermore, factors that increase bone resorption, independent of tumor, such as sex steroid deficiency, may contribute to this vicious cycle of tumor growth in bone. This article discusses mechanisms and therapeutic implications of osteolytic and osteoblastic bone metastases.

Original languageEnglish (US)
Pages (from-to)6213s-6216s
JournalClinical Cancer Research
Issue number20 PART 2
StatePublished - Oct 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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