Baseline disability and poor functioning in Bipolar disorder predict worse outcomes: Results from the Bipolar CHOICE study

Thilo Deckersbach, Andrew A. Nierenberg, Melvin G. McInnis, Stephanie Salcedo, Emily E. Bernstein, David E. Kemp, Richard C. Shelton, Susan L. McElroy, Louisa G. Sylvia, James H. Kocsis, William V. Bobo, Edward S. Friedman, Vivek Singh, Mauricio Tohen, Charles L. Bowden, Terence A. Ketter, Joseph R. Calabrese, Michael E. Thase, Noreen A. Reilly-Harrington, Dustin J. RabideauGustavo Kinrys, Masoud Kamali

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Objective: To examine the effects of treatment on functioning impairments and quality of life and assess baseline functioning and employment status as predictors of treatment response in symptomatic individuals from the Bipolar Clinical Health Outcomes Initiative in Comparative Effectiveness (Bipolar CHOICE) study. Method: Bipolar CHOICE was an 11-site, 6-month randomized effectiveness study comparing lithium to quetiapine, each with adjunctive personalized treatments (APTs). We examined post hoc (1) the effects of treatment on functioning, (2) how changes in functioning differed between treatment responders and nonresponders, and (3) whether functioning and employment status mediated treatment response in 482 participants with DSM-IV-TR bipolar I or II disorder from September 2010 to September 2013. Results: Treatment was associated with significant improvements in functioning and quality of life, regardless of treatment group (P values

Original languageEnglish (US)
Pages (from-to)100-108
Number of pages9
JournalJournal of Clinical Psychiatry
Volume77
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Deckersbach, T., Nierenberg, A. A., McInnis, M. G., Salcedo, S., Bernstein, E. E., Kemp, D. E., Shelton, R. C., McElroy, S. L., Sylvia, L. G., Kocsis, J. H., Bobo, W. V., Friedman, E. S., Singh, V., Tohen, M., Bowden, C. L., Ketter, T. A., Calabrese, J. R., Thase, M. E., Reilly-Harrington, N. A., ... Kamali, M. (2016). Baseline disability and poor functioning in Bipolar disorder predict worse outcomes: Results from the Bipolar CHOICE study. Journal of Clinical Psychiatry, 77(1), 100-108. https://doi.org/10.4088/JCP.14m09210