Basal-like breast cancers

Oluwole Fadare, I. Tien Yeh

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Cluster analysis of data derived from complementary DNA microarrays has demonstrated that breast cancers are divisible into at least 5 molecular subclasses. Basal-like breast cancers represent 1 of these subclasses. These tumors constitute approximately 20% of breast cancers, show overexpression of genes and proteins characteristic of the normal myoepithelial cell, and have been associated with a worse overall and disease-free survival as compared with most of the other subclasses. In this article, we present a case of basal-like breast cancer and summarize the rapidly expanding literature on the most salient clinicopathologic attributes of breast cancers classified as "basal-like" by gene expression profiling and/or immunohistochemical criteria.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalPathology Case Reviews
Volume12
Issue number4
DOIs
StatePublished - Jul 1 2007

Keywords

  • Basal-like
  • Basal-type
  • Breast
  • Carcinoma
  • Gene expression profiling
  • Pathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Fingerprint Dive into the research topics of 'Basal-like breast cancers'. Together they form a unique fingerprint.

  • Cite this