Abstract
Cluster analysis of data derived from complementary DNA microarrays has demonstrated that breast cancers are divisible into at least 5 molecular subclasses. Basal-like breast cancers represent 1 of these subclasses. These tumors constitute approximately 20% of breast cancers, show overexpression of genes and proteins characteristic of the normal myoepithelial cell, and have been associated with a worse overall and disease-free survival as compared with most of the other subclasses. In this article, we present a case of basal-like breast cancer and summarize the rapidly expanding literature on the most salient clinicopathologic attributes of breast cancers classified as "basal-like" by gene expression profiling and/or immunohistochemical criteria.
Original language | English (US) |
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Pages (from-to) | 143-153 |
Number of pages | 11 |
Journal | Pathology Case Reviews |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2007 |
Keywords
- Basal-like
- Basal-type
- Breast
- Carcinoma
- Gene expression profiling
- Pathology
ASJC Scopus subject areas
- Pathology and Forensic Medicine