Abstract
Barrett’s esophagus (BE) is a change in the distal esophageal mucosal lining, whereby metaplastic columnar epithelium replaces squamous epithelium of the esophagus. This change represents a pre-malignant mucosal transformation which has a known association with the development of esophageal adenocarcinoma. Gastroesophageal reflux disease is a risk factor for BE, other risk factors include patients who are Caucasian, age > 50 years, central obesity, tobacco use, history of peptic stricture and erosive gastritis. Screening for BE remains selective based on risk factors, a screening program in the general population is not routinely recommended. Diagnosis of BE is established with a combination of endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. We aim to provide a comprehensive review of the epidemiology, pathogenesis, screening and advanced techniques of detecting and eradicating Barrett’s esophagus.
Original language | English (US) |
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Article number | 321 |
Journal | Diagnostics |
Volume | 13 |
Issue number | 2 |
DOIs | |
State | Published - Jan 2023 |
Keywords
- Barrett’s esophagus
- dysplasia
- esophageal adenocarcinoma
- intestinal metaplasia
- metaplasia
ASJC Scopus subject areas
- Clinical Biochemistry