Barrett’s Esophagus: An Updated Review

Peter M. Stawinski, Karolina N. Dziadkowiec, Lily A. Kuo, Juan Echavarria, Shreyas Saligram

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Barrett’s esophagus (BE) is a change in the distal esophageal mucosal lining, whereby metaplastic columnar epithelium replaces squamous epithelium of the esophagus. This change represents a pre-malignant mucosal transformation which has a known association with the development of esophageal adenocarcinoma. Gastroesophageal reflux disease is a risk factor for BE, other risk factors include patients who are Caucasian, age > 50 years, central obesity, tobacco use, history of peptic stricture and erosive gastritis. Screening for BE remains selective based on risk factors, a screening program in the general population is not routinely recommended. Diagnosis of BE is established with a combination of endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. We aim to provide a comprehensive review of the epidemiology, pathogenesis, screening and advanced techniques of detecting and eradicating Barrett’s esophagus.

Original languageEnglish (US)
Article number321
JournalDiagnostics
Volume13
Issue number2
DOIs
StatePublished - Jan 2023

Keywords

  • Barrett’s esophagus
  • dysplasia
  • esophageal adenocarcinoma
  • intestinal metaplasia
  • metaplasia

ASJC Scopus subject areas

  • Clinical Biochemistry

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