Balloon-expandable intracoronary stents in the adult dog

R. A. Schatz, Julio C Palmaz, F. O. Tio, F. Garcia, O. Garcia, S. R. Reuter

Research output: Contribution to journalArticle

284 Citations (Scopus)

Abstract

We studied the acute and chronic biological reaction to balloon-expandable intracoronary stents in the adult dog. Twenty stainless steel stents were placed, by standard angioplasty techniques, into the left anterior descending, left main, or circumflex coronary arteries of 20 dogs. Angiography was performed at 1, 3, 6 and 12 months and animals were killed in groups of three at 1, 3, 8, and 32 weeks, for gross, light, and electronmicroscopic analysis. All dogs survived, all stents were patent, and there was no evidence of myocardial infarction, spasm, rupture, or aneurysm formation during follow-up (longest 18 months; average, 12 months). The stent was initially covered by a thin layer of thrombus that was replaced later by neointimal muscular proliferation that reached its maximal thickness by 8 weeks (p < .01). This neointima gradually thinned as it became more sclerotic and less cellular. The stents were covered completely by immature endothelium by 1 week without loss of side branches. We conclude that balloon-expandable intraluminal stents can be safely placed percutaneously into normal canine coronary arteries. Because of rapid endothelialization high patency rates can be expected, thus offering promise for clinical applications in man.

Original languageEnglish (US)
Pages (from-to)450-457
Number of pages8
JournalCirculation
Volume76
Issue number2
StatePublished - 1987
Externally publishedYes

Fingerprint

Stents
Dogs
Coronary Vessels
Neointima
Stainless Steel
Spasm
Angioplasty
Endothelium
Aneurysm
Canidae
Rupture
Angiography
Thrombosis
Myocardial Infarction
Light

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Schatz, R. A., Palmaz, J. C., Tio, F. O., Garcia, F., Garcia, O., & Reuter, S. R. (1987). Balloon-expandable intracoronary stents in the adult dog. Circulation, 76(2), 450-457.

Balloon-expandable intracoronary stents in the adult dog. / Schatz, R. A.; Palmaz, Julio C; Tio, F. O.; Garcia, F.; Garcia, O.; Reuter, S. R.

In: Circulation, Vol. 76, No. 2, 1987, p. 450-457.

Research output: Contribution to journalArticle

Schatz, RA, Palmaz, JC, Tio, FO, Garcia, F, Garcia, O & Reuter, SR 1987, 'Balloon-expandable intracoronary stents in the adult dog', Circulation, vol. 76, no. 2, pp. 450-457.
Schatz RA, Palmaz JC, Tio FO, Garcia F, Garcia O, Reuter SR. Balloon-expandable intracoronary stents in the adult dog. Circulation. 1987;76(2):450-457.
Schatz, R. A. ; Palmaz, Julio C ; Tio, F. O. ; Garcia, F. ; Garcia, O. ; Reuter, S. R. / Balloon-expandable intracoronary stents in the adult dog. In: Circulation. 1987 ; Vol. 76, No. 2. pp. 450-457.
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