Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart

Ju Fang Wang; Dhadendra Tomar; Thomas G. Martin; Shubham Dubey; Praveen K. Dubey; Jianliang Song; Gavin Landesberg; Michael G. McCormick; Valerie D. Myers; Salim Merali; Carmen Merali; Bonnie Lemster; Charles F. McTiernan; Kamel Khalili; Muniswamy Madesh; Joseph Y. Cheung; Jonathan A. Kirk; Arthur M. Feldman

doi:10.1016/j.jacbts.2022.12.013

Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart

Ju Fang Wang, Dhadendra Tomar, Thomas G. Martin, Shubham Dubey, Praveen K. Dubey, Jianliang Song, Gavin Landesberg, Michael G. McCormick, Valerie D. Myers, Salim Merali, Carmen Merali, Bonnie Lemster, Charles F. McTiernan, Kamel Khalili, Muniswamy Madesh, Joseph Y. Cheung, Jonathan A. Kirk, Arthur M. Feldman

Division of Cardiology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome.

Original language	English (US)
Pages (from-to)	820-839
Number of pages	20
Journal	JACC: Basic to Translational Science
Volume	8
Issue number	7
DOIs	https://doi.org/10.1016/j.jacbts.2022.12.013
State	Published - Jul 2023

Keywords

Bcl2-associated athanogene-3
apoptosis
caspase
metabolism
tumor necrosis factor

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2022.12.013

Cite this

Wang, J. F., Tomar, D., Martin, T. G., Dubey, S., Dubey, P. K., Song, J., Landesberg, G., McCormick, M. G., Myers, V. D., Merali, S., Merali, C., Lemster, B., McTiernan, C. F., Khalili, K., Madesh, M., Cheung, J. Y., Kirk, J. A., & Feldman, A. M. (2023). Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart. JACC: Basic to Translational Science, 8(7), 820-839. https://doi.org/10.1016/j.jacbts.2022.12.013

Wang, JF, Tomar, D, Martin, TG, Dubey, S, Dubey, PK, Song, J, Landesberg, G, McCormick, MG, Myers, VD, Merali, S, Merali, C, Lemster, B, McTiernan, CF, Khalili, K, Madesh, M, Cheung, JY, Kirk, JA & Feldman, AM 2023, 'Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart', JACC: Basic to Translational Science, vol. 8, no. 7, pp. 820-839. https://doi.org/10.1016/j.jacbts.2022.12.013

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title = "Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart",

abstract = "B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome.",

keywords = "Bcl2-associated athanogene-3, apoptosis, caspase, metabolism, tumor necrosis factor",

author = "Wang, {Ju Fang} and Dhadendra Tomar and Martin, {Thomas G.} and Shubham Dubey and Dubey, {Praveen K.} and Jianliang Song and Gavin Landesberg and McCormick, {Michael G.} and Myers, {Valerie D.} and Salim Merali and Carmen Merali and Bonnie Lemster and McTiernan, {Charles F.} and Kamel Khalili and Muniswamy Madesh and Cheung, {Joseph Y.} and Kirk, {Jonathan A.} and Feldman, {Arthur M.}",

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doi = "10.1016/j.jacbts.2022.12.013",

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AU - Wang, Ju Fang

AU - Tomar, Dhadendra

AU - Martin, Thomas G.

AU - Dubey, Shubham

AU - Dubey, Praveen K.

AU - Song, Jianliang

AU - Landesberg, Gavin

AU - McCormick, Michael G.

AU - Myers, Valerie D.

AU - Merali, Salim

AU - Merali, Carmen

AU - Lemster, Bonnie

AU - McTiernan, Charles F.

AU - Khalili, Kamel

AU - Madesh, Muniswamy

AU - Cheung, Joseph Y.

AU - Kirk, Jonathan A.

AU - Feldman, Arthur M.

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AB - B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome.

KW - Bcl2-associated athanogene-3

KW - apoptosis

KW - caspase

KW - metabolism

KW - tumor necrosis factor

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Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart

Abstract

Keywords

ASJC Scopus subject areas

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