Bag3 Regulates Mitochondrial Function and the Inflammasome Through Canonical and Noncanonical Pathways in the Heart

Ju Fang Wang, Dhadendra Tomar, Thomas G. Martin, Shubham Dubey, Praveen K. Dubey, Jianliang Song, Gavin Landesberg, Michael G. McCormick, Valerie D. Myers, Salim Merali, Carmen Merali, Bonnie Lemster, Charles F. McTiernan, Kamel Khalili, Muniswamy Madesh, Joseph Y. Cheung, Jonathan A. Kirk, Arthur M. Feldman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

B-cell lymphoma 2–associated athanogene-3 (Bag3) is expressed in all animal species, with Bag3 levels being most prominent in the heart, the skeletal muscle, the central nervous system, and in many cancers. Preclinical studies of Bag3 biology have focused on animals that have developed compromised cardiac function; however, the present studies were performed to identify the pathways perturbed in the heart even before the occurrence of clinical signs of dilatation and failure of the heart. These studies show that hearts carrying variants that knockout one allele of BAG3 have significant alterations in multiple cellular pathways including apoptosis, autophagy, mitochondrial homeostasis, and the inflammasome.

Original languageEnglish (US)
Pages (from-to)820-839
Number of pages20
JournalJACC: Basic to Translational Science
Volume8
Issue number7
DOIs
StatePublished - Jul 2023
Externally publishedYes

Keywords

  • Bcl2-associated athanogene-3
  • apoptosis
  • caspase
  • metabolism
  • tumor necrosis factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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