Bacteriophages and endotoxin in licensed live virus vaccines

E. E.M. Moody, M. D. Trousdale, J. H. Jorgensen, A. Shelokov

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In confirmation of recent reports, coliphages were found in seven of 19 unselected samples of the currently licensed live virus vaccines. Coliphages and pseudomonas phages were found in 11 and 14, respectively, of the 20 bovine sera commonly used in the cell culture phase of virus vaccine production. The same lots of vaccine and serum were examined by the limulus assay for endotoxin, another product of bacterial contamination. Eighteen of 20 sera had detectable endotoxin like activity. These preliminary results suggest that endotoxin activity may serve as a sensitive indicator of residual products of previous bacterial contamination, including bacteriophages.

Original languageEnglish (US)
Pages (from-to)588-591
Number of pages4
JournalJournal of Infectious Diseases
Volume131
Issue number5
DOIs
StatePublished - Jan 1 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Moody, E. E. M., Trousdale, M. D., Jorgensen, J. H., & Shelokov, A. (1975). Bacteriophages and endotoxin in licensed live virus vaccines. Journal of Infectious Diseases, 131(5), 588-591. https://doi.org/10.1093/infdis/131.5.588