Bacteriophages and endotoxin in licensed live virus vaccines

E. E.M. Moody, M. D. Trousdale, J. H. Jorgensen, A. Shelokov

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


In confirmation of recent reports, coliphages were found in seven of 19 unselected samples of the currently licensed live virus vaccines. Coliphages and pseudomonas phages were found in 11 and 14, respectively, of the 20 bovine sera commonly used in the cell culture phase of virus vaccine production. The same lots of vaccine and serum were examined by the limulus assay for endotoxin, another product of bacterial contamination. Eighteen of 20 sera had detectable endotoxin like activity. These preliminary results suggest that endotoxin activity may serve as a sensitive indicator of residual products of previous bacterial contamination, including bacteriophages.

Original languageEnglish (US)
Pages (from-to)588-591
Number of pages4
JournalJournal of Infectious Diseases
Issue number5
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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