TY - JOUR
T1 - Bacterial-host interactions
T2 - Physiology and pathophysiology of respiratory infection
AU - Hakansson, A. P.
AU - Orihuela, C. J.
AU - Bogaert, D.
N1 - Funding Information:
This work was supported by Division of Intramural Research, National Institute of Allergy and Infectious Diseases Grant AI114800, National Institute of General Medical Sciences Grant AI117309-01, National Institute on Deafness and Other Communication Disorders Grant AI121614-01, National Institute on Aging (U.S. National Institute on Aging) Grant AG055144, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) Grant vidi-91715359, and the Chief Scientist Office Grant SCAD/16/03.
Funding Information:
This work was supported by Division of Intramural Research, National Institute of Allergy and Infectious Diseases Grant AI114800, National Institute of General Medical Sciences Grant AI117309-01, National Institute on Deafness and Other Communication Disorders Grant AI121614-01, National Institute on Aging (U.S. National Institute on Aging) Grant AG055144, Nederlandse Organi-satie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) Grant vidi-91715359, and the Chief Scientist Office Grant SCAD/16/03.
PY - 2018/4
Y1 - 2018/4
N2 - It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has become apparent that in contrast to this classical view, the majority of microorganisms associated with respiratory infections and inflammation are actually common members of the respiratory ecosystem and only in rare circumstances do they cause disease. This suggests that a complex interplay between host, environment, and properties of colonizing microorganisms together determines disease development and its severity. To understand the pathophysiological processes that underlie respiratory infectious diseases, it is therefore necessary to understand the host-bacterial interactions occurring at mucosal surfaces, along with the microbes inhabiting them, during symbiosis. Current knowledge regarding host-bacterial interactions during asymptomatic colonization will be discussed, including a plausible role for the human microbiome in maintaining a healthy state. With this as a starting point, we will discuss possible disruptive factors contributing to dysbiosis, which is likely to be a key trigger for pathobionts in the development and pathophysiology of respiratory diseases. Finally, from this renewed perspective, we will reflect on current and potential new approaches for treatment in the future.
AB - It has long been thought that respiratory infections are the direct result of acquisition of pathogenic viruses or bacteria, followed by their overgrowth, dissemination, and in some instances tissue invasion. In the last decades, it has become apparent that in contrast to this classical view, the majority of microorganisms associated with respiratory infections and inflammation are actually common members of the respiratory ecosystem and only in rare circumstances do they cause disease. This suggests that a complex interplay between host, environment, and properties of colonizing microorganisms together determines disease development and its severity. To understand the pathophysiological processes that underlie respiratory infectious diseases, it is therefore necessary to understand the host-bacterial interactions occurring at mucosal surfaces, along with the microbes inhabiting them, during symbiosis. Current knowledge regarding host-bacterial interactions during asymptomatic colonization will be discussed, including a plausible role for the human microbiome in maintaining a healthy state. With this as a starting point, we will discuss possible disruptive factors contributing to dysbiosis, which is likely to be a key trigger for pathobionts in the development and pathophysiology of respiratory diseases. Finally, from this renewed perspective, we will reflect on current and potential new approaches for treatment in the future.
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U2 - 10.1152/physrev.00040.2016
DO - 10.1152/physrev.00040.2016
M3 - Article
AN - SCOPUS:85043788881
VL - 98
SP - 781
EP - 811
JO - Physiological Reviews
JF - Physiological Reviews
SN - 0031-9333
IS - 2
ER -