Bacterial Endocarditis and Cerebrovascular Disease

Brian Silver, Réza Behrouz, Scott Silliman

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Cerebrovascular complications of endocarditis occur in 25–70% of patients with infective endocarditis. The cornerstone of treatment is early initiation of antibiotic treatment, which significantly reduces the risk of embolization after 1 week of treatment. In general, thrombolysis and anticoagulation of these patients should be avoided, while antiplatelet therapy may be considered in those with other indications. Endovascular treatment of acute septic emboli is uncertain, but a few case reports have demonstrated benefit. Other complications of infective endocarditis include intracerebral hemorrhage, which may be predicted by the presence of two or more cerebral microbleeds on gradient echo sequences. Intracranial mycotic aneurysms can often be managed with serial imaging and coiled if there is evidence of failure to reduce in size, or enlargement.

Original languageEnglish (US)
Article number104
JournalCurrent Neurology and Neuroscience Reports
Issue number12
StatePublished - Dec 1 2016


  • Endocarditis
  • Review
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • General Neuroscience


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