Abstract
Objective: To determine whether or not patients with refractory interstitial cystitis who had failed conservative therapy might benefit from intravesical bacillus Calmette-Guérin (BCG) immunotherapy. Method: Five patients with refractory interstitial cystitis who had failed conservativetherapy underwent six weekly treatments with intravesical BCG. All 5 patients were evaluated before therapy and quarterly thereafter by water cystometry and symptom questionnaire. Results: The average number of medications used daily per patient decreased from 3.2 to 1.2 after therapy. Average volumes of both first desire to void and cystometric capacity doubled after BCG. Improvement in cystometric capacity, average daytime urinary frequency, nocturia, and global pain/discomfort were statistically significant (P = 0.0277, P = 0.0131, P = 0.0199, and P = 0.0317, respectively). Three patients experienced near total relief of their symptoms with six to twelve months' follow-up (average follow-up equals 33.6 weeks). Conclusions: Although the mechanism of action of BCG in interstitial cystitis is unknown,we recommend a double-blind placebo controlled trial to confirm these results and determine an optimal dosage and treatment schedule.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 121-124 |
| Number of pages | 4 |
| Journal | Urology |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Urology
Cite this
Bacillus Calmette-Guérin immunotherapy for refractory interstitial cystitis. / Zeidman, Eric J.; Helfrick, Barbi; Pollard, Catherine; Thompson, Ian M.
In: Urology, Vol. 43, No. 1, 1994, p. 121-124.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bacillus Calmette-Guérin immunotherapy for refractory interstitial cystitis
AU - Zeidman, Eric J.
AU - Helfrick, Barbi
AU - Pollard, Catherine
AU - Thompson, Ian M.
PY - 1994
Y1 - 1994
N2 - Objective: To determine whether or not patients with refractory interstitial cystitis who had failed conservative therapy might benefit from intravesical bacillus Calmette-Guérin (BCG) immunotherapy. Method: Five patients with refractory interstitial cystitis who had failed conservativetherapy underwent six weekly treatments with intravesical BCG. All 5 patients were evaluated before therapy and quarterly thereafter by water cystometry and symptom questionnaire. Results: The average number of medications used daily per patient decreased from 3.2 to 1.2 after therapy. Average volumes of both first desire to void and cystometric capacity doubled after BCG. Improvement in cystometric capacity, average daytime urinary frequency, nocturia, and global pain/discomfort were statistically significant (P = 0.0277, P = 0.0131, P = 0.0199, and P = 0.0317, respectively). Three patients experienced near total relief of their symptoms with six to twelve months' follow-up (average follow-up equals 33.6 weeks). Conclusions: Although the mechanism of action of BCG in interstitial cystitis is unknown,we recommend a double-blind placebo controlled trial to confirm these results and determine an optimal dosage and treatment schedule.
AB - Objective: To determine whether or not patients with refractory interstitial cystitis who had failed conservative therapy might benefit from intravesical bacillus Calmette-Guérin (BCG) immunotherapy. Method: Five patients with refractory interstitial cystitis who had failed conservativetherapy underwent six weekly treatments with intravesical BCG. All 5 patients were evaluated before therapy and quarterly thereafter by water cystometry and symptom questionnaire. Results: The average number of medications used daily per patient decreased from 3.2 to 1.2 after therapy. Average volumes of both first desire to void and cystometric capacity doubled after BCG. Improvement in cystometric capacity, average daytime urinary frequency, nocturia, and global pain/discomfort were statistically significant (P = 0.0277, P = 0.0131, P = 0.0199, and P = 0.0317, respectively). Three patients experienced near total relief of their symptoms with six to twelve months' follow-up (average follow-up equals 33.6 weeks). Conclusions: Although the mechanism of action of BCG in interstitial cystitis is unknown,we recommend a double-blind placebo controlled trial to confirm these results and determine an optimal dosage and treatment schedule.
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U2 - 10.1016/S0090-4295(94)80284-X
DO - 10.1016/S0090-4295(94)80284-X
M3 - Article
VL - 43
SP - 121
EP - 124
JO - Urology
JF - Urology
SN - 0090-4295
IS - 1
ER -