B cell contribution of the CD4+ T cell inflammatory phenotypes in systemic lupus erythematosus

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Systemic lupus erythematosus is an autoimmune disease in which the effector molecules responsible for tissue damage are antibodies directed against a large number of self-antigens, among which nucleic acids complexed with proteins play a prominent role. These pathogenic autoantibodies are produced by plasma cells differentiated from activated autoreactive B cells, a process that requires complex interactions between multiple components of the immune systems. A key step in the activation of autoreactive B cells is provided by CD4+T cells through cytokines and cell-to-cell contact. Lupus CD4+T cells are autoreactive and they present an activated inflammatory phenotype that has been shown to contribute to disease. In addition to their role in antibody production, B cells have other effector functions, the most important ones being antigen presentation to and co-stimulation of CD4+T cells, as well as the secretion of cytokines. Here, we review what is known, largely based on mouse models, how these B cell effector functions contribute to the CD4+T cell inflammatory phenotypes in lupus. When possible, we compare CD4+T cell activation by B cells and by dendritic cells, and speculate how these interactions may contribute to the disease process.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
Issue number1
StatePublished - Jan 2 2017
Externally publishedYes


  • B1-a cells
  • Follicular helper T cells
  • Th17
  • Treg
  • marginal zone B cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'B cell contribution of the CD4+ T cell inflammatory phenotypes in systemic lupus erythematosus'. Together they form a unique fingerprint.

Cite this