Azoles

George R. Thompson; Thomas F. Patterson

doi:10.1007/978-90-481-2408-4_15

Azoles

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The treatment of invasive aspergillosis remains difficult and until recently only polyenes and itraconazole were viable treatment options. However the development of newer triazoles (voriconazole, posaconazole) has been a welcome addition to the antifungal armamentarium. The proven efficacy of prophylactic posaconazole in high-risk patients, and the use of voriconazole during treatment of invasive aspergillosis have largely replaced amphotericin B and itraconazole use for these indications. Other extended-spectrum triazoles in preclinical development (ravuconazole, isavuconazole, and albaconazole) offer additional pharmacodynamic/pharmacokinetic advantages and will also be reviewed.

Original language	English (US)
Title of host publication	Aspergillosis
Subtitle of host publication	From Diagnosis to Prevention
Publisher	Springer Netherlands
Pages	231-262
Number of pages	32
ISBN (Electronic)	9789048124084
ISBN (Print)	9789048124077
DOIs	https://doi.org/10.1007/978-90-481-2408-4_15
State	Published - 2010

Keywords

Albaconazole
Isavuconazole
Itraconazole
Posaconazole
Ravuconazole
Triazoles
Voriconazole

ASJC Scopus subject areas

General Medicine

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10.1007/978-90-481-2408-4_15

Cite this

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abstract = "The treatment of invasive aspergillosis remains difficult and until recently only polyenes and itraconazole were viable treatment options. However the development of newer triazoles (voriconazole, posaconazole) has been a welcome addition to the antifungal armamentarium. The proven efficacy of prophylactic posaconazole in high-risk patients, and the use of voriconazole during treatment of invasive aspergillosis have largely replaced amphotericin B and itraconazole use for these indications. Other extended-spectrum triazoles in preclinical development (ravuconazole, isavuconazole, and albaconazole) offer additional pharmacodynamic/pharmacokinetic advantages and will also be reviewed.",

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AU - Patterson, Thomas F.

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AB - The treatment of invasive aspergillosis remains difficult and until recently only polyenes and itraconazole were viable treatment options. However the development of newer triazoles (voriconazole, posaconazole) has been a welcome addition to the antifungal armamentarium. The proven efficacy of prophylactic posaconazole in high-risk patients, and the use of voriconazole during treatment of invasive aspergillosis have largely replaced amphotericin B and itraconazole use for these indications. Other extended-spectrum triazoles in preclinical development (ravuconazole, isavuconazole, and albaconazole) offer additional pharmacodynamic/pharmacokinetic advantages and will also be reviewed.

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KW - Itraconazole

KW - Posaconazole

KW - Ravuconazole

KW - Triazoles

KW - Voriconazole

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ER -

Azoles

Abstract

Keywords

ASJC Scopus subject areas

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