Azelaic and pimelic acids: Metabolic intermediates or artefacts?

M. J. Bennett; M. C. Ragni; I. Hood; D. E. Hale

doi:10.1007/BF01799635

Azelaic and pimelic acids: Metabolic intermediates or artefacts?

M. J. Bennett, M. C. Ragni, I. Hood, D. E. Hale

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.

Original language	English (US)
Pages (from-to)	220-223
Number of pages	4
Journal	Journal of Inherited Metabolic Disease
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/BF01799635
State	Published - Mar 1992
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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title = "Azelaic and pimelic acids: Metabolic intermediates or artefacts?",

abstract = "Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.",

author = "Bennett, {M. J.} and Ragni, {M. C.} and I. Hood and Hale, {D. E.}",

year = "1992",

month = mar,

doi = "10.1007/BF01799635",

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journal = "Journal of Inherited Metabolic Disease",

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T1 - Azelaic and pimelic acids

T2 - Metabolic intermediates or artefacts?

AU - Bennett, M. J.

AU - Ragni, M. C.

AU - Hood, I.

AU - Hale, D. E.

PY - 1992/3

Y1 - 1992/3

N2 - Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.

AB - Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.

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JF - Journal of Inherited Metabolic Disease

SN - 0141-8955

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ER -

Azelaic and pimelic acids: Metabolic intermediates or artefacts?

Abstract

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