Azelaic and pimelic acids: Metabolic intermediates or artefacts?

M. J. Bennett, M. C. Ragni, I. Hood, D. E. Hale

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of peroxisomal β-oxidation, for which they are of significant diagnostic value. We have detected the presence of azelaic, pimelic and even-chain-length dicarboxylic acids (adipic, suberic and sebacic acids) arising artefactually as a result of storage of small sample volumes in plastic containers. Storage of samples for organic acid analysis in glass containers is recommended.

Original languageEnglish (US)
Pages (from-to)220-223
Number of pages4
JournalJournal of Inherited Metabolic Disease
Volume15
Issue number2
DOIs
StatePublished - Mar 1 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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