Azaftig, a urinary proteoglycan from a cachectic cancer patient, causes profound weight loss in mice

Julio Figueroa; Parakat Vijayagopal; Chittaranjan Debata; Anand Prasad; Chandan Prasad

doi:10.1016/S0024-3205(99)00069-7

Azaftig, a urinary proteoglycan from a cachectic cancer patient, causes profound weight loss in mice

Julio Figueroa, Parakat Vijayagopal, Chittaranjan Debata, Anand Prasad, Chandan Prasad

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weight loss. When given to mice, the purified azaftig resulted in a significant decrease in body weight and body fat without any effect on appetite. The results of these studies show that azaftig may be one of the many factors participating in the emergence of the cathectic state.

Original language	English (US)
Pages (from-to)	1339-1347
Number of pages	9
Journal	Life Sciences
Volume	64
Issue number	15
DOIs	https://doi.org/10.1016/S0024-3205(99)00069-7
State	Published - Mar 5 1999
Externally published	Yes

Keywords

AIDS
Azaftig
Cachexia
Cancer
Fat loss

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/S0024-3205(99)00069-7

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abstract = "Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weight loss. When given to mice, the purified azaftig resulted in a significant decrease in body weight and body fat without any effect on appetite. The results of these studies show that azaftig may be one of the many factors participating in the emergence of the cathectic state.",

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AU - Figueroa, Julio

AU - Vijayagopal, Parakat

AU - Debata, Chittaranjan

AU - Prasad, Anand

AU - Prasad, Chandan

PY - 1999/3/5

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N2 - Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weight loss. When given to mice, the purified azaftig resulted in a significant decrease in body weight and body fat without any effect on appetite. The results of these studies show that azaftig may be one of the many factors participating in the emergence of the cathectic state.

AB - Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weight loss. When given to mice, the purified azaftig resulted in a significant decrease in body weight and body fat without any effect on appetite. The results of these studies show that azaftig may be one of the many factors participating in the emergence of the cathectic state.

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KW - Azaftig

KW - Cachexia

KW - Cancer

KW - Fat loss

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Azaftig, a urinary proteoglycan from a cachectic cancer patient, causes profound weight loss in mice

Abstract

Keywords

ASJC Scopus subject areas

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