Azaftig, a urinary proteoglycan from a cachectic cancer patient, causes profound weight loss in mice

Julio Figueroa, Parakat Vijayagopal, Chittaranjan Debata, Anand Prasad, Chandan Prasad

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cachexia is a complex medical condition characterized by significant weight loss associated with decreased body fat and protein; the condition may present itself with or without anorexia. We have isolated and partially characterized a proteoglycan (azaftig) from the urine of cancer and AIDS patients experiencing weight loss. When given to mice, the purified azaftig resulted in a significant decrease in body weight and body fat without any effect on appetite. The results of these studies show that azaftig may be one of the many factors participating in the emergence of the cathectic state.

Original languageEnglish (US)
Pages (from-to)1339-1347
Number of pages9
JournalLife Sciences
Volume64
Issue number15
DOIs
StatePublished - Mar 5 1999
Externally publishedYes

Keywords

  • AIDS
  • Azaftig
  • Cachexia
  • Cancer
  • Fat loss

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Fingerprint Dive into the research topics of 'Azaftig, a urinary proteoglycan from a cachectic cancer patient, causes profound weight loss in mice'. Together they form a unique fingerprint.

Cite this