Axonal Ensheathment and Intercellular Barrier Formation in Drosophila

Kevin Blauth, Swati Banerjee, Manzoor Bhat

Research output: Book/ReportBook

7 Citations (Scopus)

Abstract

Glial cells are critical players in every major aspect of nervous system development, function, and disease. Other than their traditional supportive role, glial cells perform a variety of important functions such as myelination, synapse formation and plasticity, and establishment of blood-brain and blood-nerve barriers in the nervous system. Recent studies highlight the striking functional similarities between Drosophila and vertebrate glia. In both systems, glial cells play an essential role in neural ensheathment thereby isolating the nervous system and help to create a local ionic microenvironment for conduction of nerve impulses. Here, we review the anatomical aspects and the molecular players that underlie ensheathment during different stages of nervous system development in Drosophila and how these processes lead to the organization of neuroglial junctions. We also discuss some key aspects of the invertebrate axonal ensheathment and junctional organization with that of vertebrate myelination and axon-glial interactions. Finally, we highlight the importance of intercellular junctions in barrier formation in various cellular contexts in Drosophila. We speculate that unraveling the genetic and molecular mechanisms of ensheathment across species might provide key insights into human myelin-related disorders and help in designing therapeutic interventions.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages36
Volume283
EditionC
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameInternational Review of Cell and Molecular Biology
No.C
Volume283
ISSN (Print)19376448

Fingerprint

Neuroglia
Drosophila
Neurology
Nervous System
Vertebrates
Blood
Blood-Nerve Barrier
Intercellular Junctions
Invertebrates
Myelin Sheath
Blood-Brain Barrier
Synapses
Action Potentials
Plasticity
Axons
Molecular Biology
Brain
Therapeutics

Keywords

  • Axonal ensheathment
  • Blood-brain barrier
  • Blood-eye barrier
  • Drosophila
  • Glia
  • Septate junctions

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Cite this

Blauth, K., Banerjee, S., & Bhat, M. (2010). Axonal Ensheathment and Intercellular Barrier Formation in Drosophila. (C ed.) (International Review of Cell and Molecular Biology; Vol. 283, No. C). Unknown Publisher. https://doi.org/10.1016/S1937-6448(10)83003-5

Axonal Ensheathment and Intercellular Barrier Formation in Drosophila. / Blauth, Kevin; Banerjee, Swati; Bhat, Manzoor.

C ed. Unknown Publisher, 2010. 36 p. (International Review of Cell and Molecular Biology; Vol. 283, No. C).

Research output: Book/ReportBook

Blauth, K, Banerjee, S & Bhat, M 2010, Axonal Ensheathment and Intercellular Barrier Formation in Drosophila. International Review of Cell and Molecular Biology, no. C, vol. 283, vol. 283, C edn, Unknown Publisher. https://doi.org/10.1016/S1937-6448(10)83003-5
Blauth K, Banerjee S, Bhat M. Axonal Ensheathment and Intercellular Barrier Formation in Drosophila. C ed. Unknown Publisher, 2010. 36 p. (International Review of Cell and Molecular Biology; C). https://doi.org/10.1016/S1937-6448(10)83003-5
Blauth, Kevin ; Banerjee, Swati ; Bhat, Manzoor. / Axonal Ensheathment and Intercellular Barrier Formation in Drosophila. C ed. Unknown Publisher, 2010. 36 p. (International Review of Cell and Molecular Biology; C).
@book{cb81e145cfc848bf981abeb62617572f,
title = "Axonal Ensheathment and Intercellular Barrier Formation in Drosophila",
abstract = "Glial cells are critical players in every major aspect of nervous system development, function, and disease. Other than their traditional supportive role, glial cells perform a variety of important functions such as myelination, synapse formation and plasticity, and establishment of blood-brain and blood-nerve barriers in the nervous system. Recent studies highlight the striking functional similarities between Drosophila and vertebrate glia. In both systems, glial cells play an essential role in neural ensheathment thereby isolating the nervous system and help to create a local ionic microenvironment for conduction of nerve impulses. Here, we review the anatomical aspects and the molecular players that underlie ensheathment during different stages of nervous system development in Drosophila and how these processes lead to the organization of neuroglial junctions. We also discuss some key aspects of the invertebrate axonal ensheathment and junctional organization with that of vertebrate myelination and axon-glial interactions. Finally, we highlight the importance of intercellular junctions in barrier formation in various cellular contexts in Drosophila. We speculate that unraveling the genetic and molecular mechanisms of ensheathment across species might provide key insights into human myelin-related disorders and help in designing therapeutic interventions.",
keywords = "Axonal ensheathment, Blood-brain barrier, Blood-eye barrier, Drosophila, Glia, Septate junctions",
author = "Kevin Blauth and Swati Banerjee and Manzoor Bhat",
year = "2010",
doi = "10.1016/S1937-6448(10)83003-5",
language = "English (US)",
volume = "283",
series = "International Review of Cell and Molecular Biology",
publisher = "Unknown Publisher",
number = "C",
edition = "C",

}

TY - BOOK

T1 - Axonal Ensheathment and Intercellular Barrier Formation in Drosophila

AU - Blauth, Kevin

AU - Banerjee, Swati

AU - Bhat, Manzoor

PY - 2010

Y1 - 2010

N2 - Glial cells are critical players in every major aspect of nervous system development, function, and disease. Other than their traditional supportive role, glial cells perform a variety of important functions such as myelination, synapse formation and plasticity, and establishment of blood-brain and blood-nerve barriers in the nervous system. Recent studies highlight the striking functional similarities between Drosophila and vertebrate glia. In both systems, glial cells play an essential role in neural ensheathment thereby isolating the nervous system and help to create a local ionic microenvironment for conduction of nerve impulses. Here, we review the anatomical aspects and the molecular players that underlie ensheathment during different stages of nervous system development in Drosophila and how these processes lead to the organization of neuroglial junctions. We also discuss some key aspects of the invertebrate axonal ensheathment and junctional organization with that of vertebrate myelination and axon-glial interactions. Finally, we highlight the importance of intercellular junctions in barrier formation in various cellular contexts in Drosophila. We speculate that unraveling the genetic and molecular mechanisms of ensheathment across species might provide key insights into human myelin-related disorders and help in designing therapeutic interventions.

AB - Glial cells are critical players in every major aspect of nervous system development, function, and disease. Other than their traditional supportive role, glial cells perform a variety of important functions such as myelination, synapse formation and plasticity, and establishment of blood-brain and blood-nerve barriers in the nervous system. Recent studies highlight the striking functional similarities between Drosophila and vertebrate glia. In both systems, glial cells play an essential role in neural ensheathment thereby isolating the nervous system and help to create a local ionic microenvironment for conduction of nerve impulses. Here, we review the anatomical aspects and the molecular players that underlie ensheathment during different stages of nervous system development in Drosophila and how these processes lead to the organization of neuroglial junctions. We also discuss some key aspects of the invertebrate axonal ensheathment and junctional organization with that of vertebrate myelination and axon-glial interactions. Finally, we highlight the importance of intercellular junctions in barrier formation in various cellular contexts in Drosophila. We speculate that unraveling the genetic and molecular mechanisms of ensheathment across species might provide key insights into human myelin-related disorders and help in designing therapeutic interventions.

KW - Axonal ensheathment

KW - Blood-brain barrier

KW - Blood-eye barrier

KW - Drosophila

KW - Glia

KW - Septate junctions

UR - http://www.scopus.com/inward/record.url?scp=77956147861&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956147861&partnerID=8YFLogxK

U2 - 10.1016/S1937-6448(10)83003-5

DO - 10.1016/S1937-6448(10)83003-5

M3 - Book

C2 - 20801419

AN - SCOPUS:77956147861

VL - 283

T3 - International Review of Cell and Molecular Biology

BT - Axonal Ensheathment and Intercellular Barrier Formation in Drosophila

PB - Unknown Publisher

ER -