TY - JOUR
T1 - Axon regeneration mechanisms
T2 - Insights from C. elegans
AU - Chen, Lizhen
AU - Chisholm, Andrew D.
N1 - Funding Information:
We thank Y. Jin for discussions and members of the Jin and Chisholm laboratories for comments. Work in our laboratory on axon regeneration is supported by the National Institutes of Health (R01 NS057317).
PY - 2011/10
Y1 - 2011/10
N2 - Understanding the mechanisms of axon regeneration is of great importance to the development of therapeutic treatments for spinal cord injury or stroke. Axon regeneration has long been studied in diverse vertebrate and invertebrate models, but until recently had not been analyzed in the genetically tractable model organism Caenorhabditis elegans. The small size, simple neuroanatomy, and transparency of C. elegans allows single fluorescently labeled axons to be severed in live animals using laser microsurgery. Many neurons in C. elegans are capable of regenerative regrowth, and can in some cases re-establish functional connections. Large-scale genetic screens have begun to elucidate the genetic basis of axon regrowth.
AB - Understanding the mechanisms of axon regeneration is of great importance to the development of therapeutic treatments for spinal cord injury or stroke. Axon regeneration has long been studied in diverse vertebrate and invertebrate models, but until recently had not been analyzed in the genetically tractable model organism Caenorhabditis elegans. The small size, simple neuroanatomy, and transparency of C. elegans allows single fluorescently labeled axons to be severed in live animals using laser microsurgery. Many neurons in C. elegans are capable of regenerative regrowth, and can in some cases re-establish functional connections. Large-scale genetic screens have begun to elucidate the genetic basis of axon regrowth.
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U2 - 10.1016/j.tcb.2011.08.003
DO - 10.1016/j.tcb.2011.08.003
M3 - Review article
C2 - 21907582
AN - SCOPUS:80053118092
SN - 0962-8924
VL - 21
SP - 577
EP - 584
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 10
ER -