@article{b36bee3bb76c41d4979c3c306265b91a,
title = "Axon-glia interactions and the domain organization of myelinated axons requires Neurexin IV/Caspr/Paranodin",
abstract = "Myelinated fibers are organized into distinct domains that are necessary for saltatory conduction. These domains include the nodes of Ranvier and the flanking paranodal regions where glial cells closely appose and form specialized septate-like junctions with axons. These junctions contain a Drosophila Neurexin IV-related protein, Caspr/Paranodin (NCP1). Mice that lack NCP1 exhibit tremor, ataxia, and significant motor paresis. In the absence of NCP1, normal paranodal junctions fail to form, and the organization of the paranodal loops is disrupted. Contactin is undetectable in the paranodes, and K+ channels are displaced from the juxtaparanodal into the paranodal domains. Loss of NCP1 also results in a severe decrease in peripheral nerve conduction velocity. These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction.",
author = "Bhat, {Manzoor A.} and Rios, {Jose C.} and Yue Lu and Garcia-Fresco, {German P.} and William Ching and Martin, {Mary St} and Jingjun Li and Steven Einheber and Mitchell Chesler and Jack Rosenbluth and Salzer, {James L.} and Bellen, {Hugo J.}",
note = "Funding Information: We are grateful to Arthur Beaudet (Baylor College of Medicine, Houston) for making his transgenic facility available for these studies. We thank Shayam Sharan, Glenn I. Fishman, and Ting-Fang Tsai for their suggestions; Jason Chiu, Teresa A. Milner, and Jody Culkin for technical assistance; Craig Gerard for sharing unpublished data; and Peter Brophy, David Colman, John Hemperly, and Jim Trimmer for kindly providing antibodies. This work was supported by the Howard Temin Career Development Award from the National Cancer Institute (KO1-CA 78437) and Mount Sinai School of Medicine start up funds (M.A.B.), NIH grants NS38208 (J.L.S.), NS37475 (J.R.), and NMSS grant RG2539 (J.R.). J.C.R and W.C. are Medical Scientist Trainees supported by NIH grant 5T32 GM07308 from NIGMS. H.J.B. is an investigator of the Howard Hughes Medical Institute.",
year = "2001",
doi = "10.1016/S0896-6273(01)00294-X",
language = "English (US)",
volume = "30",
pages = "369--383",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",
}