Avaliação da expressão de interleucina 1 beta (IL-1β) e antagonista do receptor de interleucina 1 (IL-1Ra) em pacientes com hanseníase

Translated title of the contribution: Evaluation of the expression of interleukin 1 beta (IL-1β) and interleukin 1 receptor antagonist (IL-1Ra) in leprosy patients

Rosane Dias Costa, Vanessa Amaral Mendonça, Sandra Lyon, Rachel Adriana Penido, Ana Maria Duarte Dias Costa, Marina Dias Costa, Marina Pires Nishi, Mauro Martins Teixeira, Antônio Lúcio Teixeira, Carlos Maurício De Figueiredo Antunes

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1β and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1β. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.

Translated title of the contributionEvaluation of the expression of interleukin 1 beta (IL-1β) and interleukin 1 receptor antagonist (IL-1Ra) in leprosy patients
Original languagePortuguese
Pages (from-to)99-103
Number of pages5
JournalRevista da Sociedade Brasileira de Medicina Tropical
Volume41
Issue numberSUPPL. 2
DOIs
StatePublished - 2008
Externally publishedYes

Keywords

  • IL-1β and IL-1Ra
  • Interleukins
  • Leprosy

ASJC Scopus subject areas

  • Parasitology
  • Microbiology (medical)
  • Infectious Diseases

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