Abstract
Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host's response to the etiologic agent, Mycobacterium leprae. Evidence suggests that the induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, mainly through the action of cytokines. The ELISA test was used to measure the levels of IL-1β and IL-1Ra in 37 new leprosy patients followed-up during treatment and 30 healthy controls. Peripheral blood was collected four times during the treatment of leprosy patients (MDT pretreatment, 2nd dose, 6th dose and post-MDT), and only once from the controls. The comparison of molecular levels in pre-MDT patients and controls showed a statistically significant difference for IL-1β. The results suggest the participation of this cytokine in the genesis of the immune/inflammatory process.
Translated title of the contribution | Evaluation of the expression of interleukin 1 beta (IL-1β) and interleukin 1 receptor antagonist (IL-1Ra) in leprosy patients |
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Original language | Portuguese |
Pages (from-to) | 99-103 |
Number of pages | 5 |
Journal | Revista da Sociedade Brasileira de Medicina Tropical |
Volume | 41 |
Issue number | SUPPL. 2 |
DOIs | |
State | Published - 2008 |
Externally published | Yes |
Keywords
- IL-1β and IL-1Ra
- Interleukins
- Leprosy
ASJC Scopus subject areas
- Parasitology
- Microbiology (medical)
- Infectious Diseases