Abstract
Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by polyclonal hypergammaglobulinemia, autoantibody formation, and intense tissue infiltration by lymphoid and plasma cells. These patients have a predisposition to the development of monoclonal immunoglobulins and B cell lymphomas. To study the role of B cells in this disease, we established B cell lines from three patients with benign primary SS. These B cell lines grew spontaneously without any stimulation and expressed EBV nuclear antigen. The lines secreted an autostimulatory factor which had properties of a B cell growth factor. Peripheral blood B cells from SS patients, after culture for 3 days, secreted a similar factor which stimulated the proliferation of established SS B cell lines. These results suggest that circulating B cells in SS produce an autocrine growth factor that may contribute to lymphoproliferation and ultimately to the emergence of B cell lymphomas.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 123-135 |
| Number of pages | 13 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Autostimulatory growth factors produced by Sjögren's syndrome B cell lines. / Takei, Masami; Dang, Howard; Dauphinee, Michael J.; Talal, Norman.
In: Clinical Immunology and Immunopathology, Vol. 53, No. 1, 1989, p. 123-135.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Autostimulatory growth factors produced by Sjögren's syndrome B cell lines
AU - Takei, Masami
AU - Dang, Howard
AU - Dauphinee, Michael J.
AU - Talal, Norman
PY - 1989
Y1 - 1989
N2 - Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by polyclonal hypergammaglobulinemia, autoantibody formation, and intense tissue infiltration by lymphoid and plasma cells. These patients have a predisposition to the development of monoclonal immunoglobulins and B cell lymphomas. To study the role of B cells in this disease, we established B cell lines from three patients with benign primary SS. These B cell lines grew spontaneously without any stimulation and expressed EBV nuclear antigen. The lines secreted an autostimulatory factor which had properties of a B cell growth factor. Peripheral blood B cells from SS patients, after culture for 3 days, secreted a similar factor which stimulated the proliferation of established SS B cell lines. These results suggest that circulating B cells in SS produce an autocrine growth factor that may contribute to lymphoproliferation and ultimately to the emergence of B cell lymphomas.
AB - Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by polyclonal hypergammaglobulinemia, autoantibody formation, and intense tissue infiltration by lymphoid and plasma cells. These patients have a predisposition to the development of monoclonal immunoglobulins and B cell lymphomas. To study the role of B cells in this disease, we established B cell lines from three patients with benign primary SS. These B cell lines grew spontaneously without any stimulation and expressed EBV nuclear antigen. The lines secreted an autostimulatory factor which had properties of a B cell growth factor. Peripheral blood B cells from SS patients, after culture for 3 days, secreted a similar factor which stimulated the proliferation of established SS B cell lines. These results suggest that circulating B cells in SS produce an autocrine growth factor that may contribute to lymphoproliferation and ultimately to the emergence of B cell lymphomas.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024460238&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(89)90107-4
DO - 10.1016/0090-1229(89)90107-4
M3 - Article
C2 - 2788543
AN - SCOPUS:0024460238
VL - 53
SP - 123
EP - 135
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 1
ER -