Autoregulation of spinal cord blood flow: Is the cord a microcosm of the brain?

R. Hickey, M. S. Albin, Leonid Bunegin, J. Gelineau

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

The autoradiography capability of regional areas of the brain and spinal cord was demonstrated in 18 rats anesthetized with a continuous infusion of intravenous pentothal. Blood flow was measured by the injection of radioactive microspheres (Co57, Sn113, Ru103, Sc46). Blood flow measurements were made at varying levels of mean arterial pressure (MAP) which was altered by neosynephrine to raise MAP or trimethaphan to lower MAP. Autoregulation of the spinal cord mirrored that of the brain, with an autoregulatory range of 60 to 120 mm Hg for both tissues. Within this range, cerebral blood flow (CBF) was 59.2 ± 3.2 ml/100 g/min (SEM) and spinal cord blood flow (SCBF) was 61.1 ± 3.6. There is no significant difference in CBF and SCBF in the autoregulatory range. Autoregulation was also demonstrated regionally in the left cortex, right cortex, brainstem, thalamus, cerebellum, hippocampus and cervical, thoracic and lumbar cord. This data provides a coherent reference point in establishing autoregulatory curves under barbiturate anesthesia. Further investigation of the effects of other anesthetic agents on autoregulation of the spinal cord is needed. It is possible that intraspinal cord compliance, like intracranial compliance, might be adversely affected by the effects of anesthetics on autoregulation.

Original languageEnglish (US)
Pages (from-to)1183-1189
Number of pages7
JournalStroke
Volume17
Issue number6
StatePublished - 1986

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Fetal Blood
Spinal Cord
Homeostasis
Brain
Cerebrovascular Circulation
Arterial Pressure
Compliance
Anesthetics
Trimethaphan
Thiopental
Phenylephrine
Autoradiography
Thalamus
Microspheres
Intravenous Infusions
Cerebellum
Brain Stem
Hippocampus
Anesthesia
Injections

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Hickey, R., Albin, M. S., Bunegin, L., & Gelineau, J. (1986). Autoregulation of spinal cord blood flow: Is the cord a microcosm of the brain? Stroke, 17(6), 1183-1189.

Autoregulation of spinal cord blood flow : Is the cord a microcosm of the brain? / Hickey, R.; Albin, M. S.; Bunegin, Leonid; Gelineau, J.

In: Stroke, Vol. 17, No. 6, 1986, p. 1183-1189.

Research output: Contribution to journalArticle

Hickey, R, Albin, MS, Bunegin, L & Gelineau, J 1986, 'Autoregulation of spinal cord blood flow: Is the cord a microcosm of the brain?', Stroke, vol. 17, no. 6, pp. 1183-1189.
Hickey, R. ; Albin, M. S. ; Bunegin, Leonid ; Gelineau, J. / Autoregulation of spinal cord blood flow : Is the cord a microcosm of the brain?. In: Stroke. 1986 ; Vol. 17, No. 6. pp. 1183-1189.
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