Autoradiographic studies of distribution in the liver of 198Au and 99mTc sulfur colloids

There are observable differences in the way in which the liver handles ¹⁹⁸Au and ⁹⁹T(m)c sulfur colloids. Studies were made with serial autoradiography following intravenous injection of these two colloids into mice. ¹⁹⁸Au colloid passes through three distinct stages of phagocytosis by Kupffer's cells. In sharp contrast, ⁹⁹T(m)c sulfur colloid does not.